Sensing invasive cytosolic DNA is an integral component of innate immunity. cGAS was
identified in 2013 as the major cytosolic DNA sensor that binds dsDNA to catalyze the …

Activation of the cGAS-STING pathway by cytoplasmic DNA induces the production of Type-
1 interferons. Recent advances in research suggest that the cGAS-STING pathway is …

Abstract Cyclic GMP-AMP synthase (cGAS) is an essential sensor of aberrant cytosolic DNA
for initiating innate immunity upon invading pathogens and cellular stress, which is …

Brain metastases are the most common type of brain tumours, harbouring an immune
microenvironment that can in principle be targeted via immunotherapy. Elucidating some of …

The cGAS-STING pathway and the Mevalonate Pathway are druggable targets for vaccine
adjuvant discovery. Manganese (Mn) and bisphosphonates are known to exert adjuvant …

The type I interferon signaling pathway constitutes a pivotal component of the innate
immune response, encompassing the cGAS/STING and JAK/STAT pathways. Drugs that …

Abstract Cyclic GMP‐AMP synthase (cGAS)‐stimulator of interferon genes (STING) signaling
pathway is a crucial component of innate immunity that plays a vital role in protecting against …

Excitatory toxicity is still a hot topic in the study of ischemic stroke, and related research has
focused mainly on neurons. Adenosine is an important neuromodulator that is known as a …

The cGAS-STING signaling plays pivotal roles not only in host antiviral defense but also in
various noninfectious contexts. Compared with protein-coding genes, much less was known …

Background Doublecortin-like kinase 2 (DCLK2) is a microtubule-associated protein kinase
that participates in neural development and maturation; however, whether it is involved in …