Proteins adopt different higher-order structures (HOS) to enable their unique biological
functions. Understanding the complexities of protein higher-order structures and dynamics …

The surge in the clinical use of therapeutic antibodies has reshaped the landscape of
pharmaceutical therapy for many diseases, including rare and challenging conditions …

Mass spectrometric epitope map** has become a versatile method to precisely determine
a soluble antigen's partial structure that directly interacts with an antibody in solution. Typical …

Intact transition epitope map** (ITEM) enables rapid and accurate determination of protein
antigen-derived epitopes by either epitope extraction or epitope excision. Upon formation of …

Epitope map**, which is the identification of antigenic determinants, is essential for the
design of novel antibody-based therapeutics and diagnostic tools. ITEM-THREE is a mass …

With Intact Transition Epitope Map**-Thermodynamic Weak-force Order (ITEM-TWO)
analysis in combination with molecular modeling, the phosphorylation-dependent molecular …

We have developed an electrospray mass spectrometry method which is capable to
determine antibody affinity in a gas phase experiment. A solution with the immune complex …

Intact Transition Epitope Map**—One-step Non-covalent force Exploitation (ITEM-ONE)
analysis reveals an assembled epitope on the surface of Pertuzumab, which is recognized …

Dried serum spots that are well prepared can be attractive alternatives to frozen serum
samples for shelving specimens in a medical or research center's biobank and mailing …

Rapid diagnostic tests are first-line assays for diagnosing infectious diseases, such as
malaria. To minimize false positive and false negative test results in population-screening …