Understanding schistosome biology is still a challenging mission. The reproductive biology
of this parasitic trematode is closely associated with the pathologic consequences of …

CRISPR/Cas9-based genome editing has yet to be reported in species of the
Platyhelminthes. We tested this approach by targeting omega-1 (ω1) of Schistosoma …

Helminth infections impact the health of hundreds of millions of persons globally and also
cause important economic losses in livestock farming. Methodological limitations as well as …

Because parasites have an inextricable relationship with their host, they have the potential
to serve as viral reservoirs or facilitate virus host shifts. And yet, little is known about viruses …

Background. At least 250 million people worldwide suffer from schistosomiasis, caused by
Schistosoma worms. Genome sequences for several Schistosoma species are available …

The identification and characterization of genomic safe harbor sites (GSHs) can facilitate
consistent transgene activity with minimal disruption to the host cell genome. We combined …

It has been postulated that impaired host immunity due to HIV infection reduces parasite egg
excretion. Schistosoma/HIV interactions have also been shown to differ by sex. We …

Schistosomes are parasitic helminths that cause schistosomiasis, a disease affecting circa
200 million people, primarily in underprivileged regions of the world. Schistosoma mansoni …

Platyhelminthes comprise one of the major phyla of invertebrate animals, inhabiting a wide
range of ecosystems, and one of the most successful in adapting to parasitic life. Small non …

ABSTRACT CD4 T-cell depletion is a hallmark of HIV/AIDS, but the underlying mechanism is
still unclear. We have recently shown that ataxia-telangiectasia-mutated (ATM) deficiency in …