Cellular recognition of microbial DNA is an evolutionarily conserved mechanism by which
the innate immune system detects pathogens. Cyclic GMP-AMP synthase (cGAS) and its …

The advent of immunotherapy in recent years has shown the potential to revolutionize the
treatment of cancer. Unleashing antitumor T cell responses via immune checkpoint blockade …

Traumatic brain injury (TBI) is associated with chronic psychiatric complications and
increased risk for development of neurodegenerative pathology. Aged individuals account …

The blood–brain barrier (BBB) is partially disrupted in brain tumors. Despite the gaps in the
BBB, there is an inadequate amount of pharmacological agents delivered into the brain …

PARP inhibition can enhance the efficacy of temozolomide and prolong survival in
orthotopic glioblastoma (GBM) xenografts. The aim of this study was to evaluate the …

We assessed the murine Stimulator of Interferon Genes (STING) agonist, DMXAA, for anti-
mesothelioma potential using the AE17-sOVA model that expresses ovalbumin (OVA) as a …

ABSTRACT Background Cyclic dinucleotides (CDNs) are bacterial intracellular messengers
that have demonstrated antitumor activity in melanoma and breast tumors, although their …

Vascular disrupting agents as DMXAA inhibit tumor growth only for a short period of time
followed by rapid tumor regrowth. Among others, hypoxia and presence of transcription …

Abstract Herpes simplex virus (HSV)− 1 is the most common cause of sporadic viral
encephalitis and accounts for 5–10% of cases worldwide. A key factor in host control of viral …

Brain metastasis (BM) is a common complication in cancer patients with advanced disease
and attributes to treatment failure and final mortality. Currently there are several therapeutic …