Group 9 organometallic compounds for therapeutic and bioanalytical applications

DL Ma, DSH Chan, CH Leung - Accounts of chemical research, 2014 - ACS Publications
Conspectus Compared with organic small molecules, metal complexes offer several distinct
advantages as therapeutic agents or biomolecular probes. Carbon atoms are typically …

Recent developments in G-quadruplex probes

DL Ma, Z Zhang, M Wang, L Lu, HJ Zhong… - Chemistry & Biology, 2015 - cell.com
Accumulating evidence has linked G-quadruplex structures to a number of biological
processes in vivo, including DNA replication, transcription, and genomic maintenance …

Selectively lighting up two-photon photodynamic activity in mitochondria with AIE-active iridium (III) complexes

J Liu, C **, B Yuan, X Liu, Y Chen, L Ji… - Chemical …, 2017 - pubs.rsc.org
Herein a series of mitochondria-targeted AIE (aggregation-induced emission)-active Ir (III)
complexes were designed to selectively exert one-/two-photon photodynamic activities in …

Detection of nicking endonuclease activity using a G-quadruplex-selective luminescent switch-on probe

L Lu, DSH Chan, DWJ Kwong, HZ He, CH Leung… - Chemical …, 2014 - pubs.rsc.org
A series of luminescent Ir (III) complexes were synthesised and evaluated for their ability to
act as G-quadruplex-selective probes. A novel Ir (III) complex was found to be highly …

DNA condensation induced by metal complexes

GY Li, RL Guan, LN Ji, H Chao - Coordination Chemistry Reviews, 2014 - Elsevier
DNA is stored in a highly compact, condensed phase in viruses, bacteria and eukaryotes.
Co (NH 3) 6 3+ is a well-known inorganic cation that can induce DNA condensation, and …

On-site detection of stacked genetically modified soybean based on event-specific TM-LAMP and a DNAzyme-lateral flow biosensor

N Cheng, Y Shang, Y Xu, L Zhang, Y Luo… - Biosensors and …, 2017 - Elsevier
Stacked genetically modified organisms (GMO) are becoming popular for their enhanced
production efficiency and improved functional properties, and on-site detection of stacked …

Cyclometalated iridium (III) complexes as two‐photon phosphorescent probes for specific mitochondrial dynamics tracking in living cells

C **, J Liu, Y Chen, L Zeng, R Guan… - … A European Journal, 2015 - Wiley Online Library
Five cyclometalated iridium (III) complexes with 2‐phenylimidazo [4, 5‐f][1, 10]
phenanthroline derivatives (IrL1–IrL5) were synthesized and developed to image and track …

Signal-on fluorescence biosensor for microRNA-21 detection based on DNA strand displacement reaction and Mg2+-dependent DNAzyme cleavage

HS Yin, BC Li, YL Zhou, HY Wang, MH Wang… - Biosensors and …, 2017 - Elsevier
MicroRNAs have been involved into many biological processes and are regarded as
disease biomarkers. Simple, rapid, sensitive and selective method for microRNA detection is …

A label-free and enzyme-free platform with a visible output for constructing versatile logic gates using caged G-quadruplex as the signal transducer

J Chen, J Pan, S Chen - Chemical Science, 2018 - pubs.rsc.org
A complete set of binary basic logic gates (OR, AND, NOR, NAND, INHIBT, IMPLICATION,
XOR and XNOR) is realized on a label-free and enzyme-free sensing platform using caged …

A fluorescent aptasensor for potassium ion detection-based triple-helix molecular switch

A Verdian-Doghaei, MR Housaindokht, K Abnous - Analytical biochemistry, 2014 - Elsevier
Here, a biosensor based on a quadruplex-forming aptamer for the determination of
potassium ion (K+) is presented. The aptamer was used as a molecular recognition element; …