Vascular mechanotransduction
This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …
Effects of shear stress on endothelial cells: go with the flow
Haemodynamic forces influence the functional properties of vascular endothelium.
Endothelial cells (ECs) have a variety of receptors, which sense flow and transmit …
Endothelial cells (ECs) have a variety of receptors, which sense flow and transmit …
Endothelial-to-mesenchymal transition contributes to fibro-proliferative vascular disease and is modulated by fluid shear stress
Aims Neointimal hyperplasia is a common feature of fibro-proliferative vascular disease and
characterizes initial stages of atherosclerosis. Neointimal lesions mainly comprise smooth …
characterizes initial stages of atherosclerosis. Neointimal lesions mainly comprise smooth …
Regulation of vascular smooth muscle cell turnover by endothelial cell–secreted microRNA-126: role of shear stress
Rationale: Endothelial microRNA-126 (miR-126) modulates vascular development and
angiogenesis. However, its role in the regulation of smooth muscle cell (SMC) function is …
angiogenesis. However, its role in the regulation of smooth muscle cell (SMC) function is …
Defective fluid shear stress mechanotransduction mediates hereditary hemorrhagic telangiectasia
Morphogenesis of the vascular system is strongly modulated by mechanical forces from
blood flow. Hereditary hemorrhagic telangiectasia (HHT) is an inherited autosomal …
blood flow. Hereditary hemorrhagic telangiectasia (HHT) is an inherited autosomal …
Valvular endothelial cells regulate the phenotype of interstitial cells in co-culture: effects of steady shear stress
Valvular endothelial cells interact with interstitial cells in a complex hemodynamic and
mechanical environment to maintain leaflet tissue integrity. The precise roles of each cell …
mechanical environment to maintain leaflet tissue integrity. The precise roles of each cell …
Macro-and microscale fluid flow systems for endothelial cell biology
Recent advances in microfluidics have brought forth new tools for studying flow-induced
effects on mammalian cells, with important applications in cardiovascular, bone and cancer …
effects on mammalian cells, with important applications in cardiovascular, bone and cancer …
The effects of hemodynamic force on embryonic development
JC Culver, ME Dickinson - Microcirculation, 2010 - Wiley Online Library
Microcirculation (2010) 17, 164–178. doi: 10.1111/j. 1549‐8719.2010. 00025. x Abstract
Blood vessels have long been known to respond to hemodynamic force, and several …
Blood vessels have long been known to respond to hemodynamic force, and several …
Shear stress inhibits adhesion molecule expression in vascular endothelial cells induced by coculture with smooth muscle cells
Vascular endothelial cells (ECs), which exist in close proximity to vascular smooth muscle
cells (SMCs), are constantly subjected to blood flow–induced shear stress. Although the …
cells (SMCs), are constantly subjected to blood flow–induced shear stress. Although the …
Layer-specific cell differentiation in bi-layered vascular grafts under flow perfusion
I Pennings, EE van Haaften, T Jungst, JA Bulsink… - …, 2019 - iopscience.iop.org
Bioengineered grafts have the potential to overcome the limitations of autologous and non-
resorbable synthetic vessels as vascular substitutes. However, one of the challenges in …
resorbable synthetic vessels as vascular substitutes. However, one of the challenges in …