Cell motility in cancer invasion and metastasis: insights from simple model organisms
CH Stuelten, CA Parent, DJ Montell - Nature Reviews Cancer, 2018 - nature.com
Metastasis remains the greatest challenge in the clinical management of cancer. Cell motility
is a fundamental and ancient cellular behaviour that contributes to metastasis and is …
is a fundamental and ancient cellular behaviour that contributes to metastasis and is …
EMT/MET plasticity in cancer and Go-or-Grow decisions in quiescence: the two sides of the same coin?
Epithelial mesenchymal transition (EMT) and mesenchymal epithelial transition (MET) are
genetic determinants of cellular plasticity. These programs operate in physiological …
genetic determinants of cellular plasticity. These programs operate in physiological …
Developmental analysis of bone marrow neutrophils reveals populations specialized in expansion, trafficking, and effector functions
Neutrophils are specialized innate cells that require constant replenishment from
proliferative bone marrow (BM) precursors as a result of their short half-life. Although it is …
proliferative bone marrow (BM) precursors as a result of their short half-life. Although it is …
Cancer metastasis as a non-healing wound
Most cancer deaths are caused by metastasis: recurrence of disease by disseminated
tumour cells at sites distant from the primary tumour. Large numbers of disseminated tumour …
tumour cells at sites distant from the primary tumour. Large numbers of disseminated tumour …
Cancer cell metabolic plasticity in migration and metastasis
Metabolic reprogramming is a hallmark of cancer metastasis in which cancer cells
manipulate their metabolic profile to meet the dynamic energetic requirements of the tumor …
manipulate their metabolic profile to meet the dynamic energetic requirements of the tumor …
The impact of proliferation-migration tradeoffs on phenotypic evolution in cancer
Tumors are not static masses of cells but dynamic ecosystems where cancer cells
experience constant turnover and evolve fitness-enhancing phenotypes. Selection for …
experience constant turnover and evolve fitness-enhancing phenotypes. Selection for …
Constricted migration increases DNA damage and independently represses cell cycle
Cell migration through dense tissues or small capillaries can elongate the nucleus and even
damage it, and any impact on cell cycle has the potential to affect various processes …
damage it, and any impact on cell cycle has the potential to affect various processes …
Three-Dimensional Lung Tumor Microenvironment Modulates Therapeutic Compound Responsiveness In Vitro – Implication for Drug Development
JE Ekert, K Johnson, B Strake, J Pardinas, S Jarantow… - PloS one, 2014 - journals.plos.org
Three-dimensional (3D) cell culture is gaining acceptance in response to the need for
cellular models that better mimic physiologic tissues. Spheroids are one such 3D model …
cellular models that better mimic physiologic tissues. Spheroids are one such 3D model …
Cancer-selective nanoparticles for combinatorial siRNA delivery to primary human GBM in vitro and in vivo
Novel treatments for glioblastoma (GBM) are urgently needed, particularly those which can
simultaneously target GBM cells' ability to grow and migrate. Herein, we describe a …
simultaneously target GBM cells' ability to grow and migrate. Herein, we describe a …
Rescue of DNA damage after constricted migration reveals a mechano-regulated threshold for cell cycle
Migration through 3D constrictions can cause nuclear rupture and mislocalization of nuclear
proteins, but damage to DNA remains uncertain, as does any effect on cell cycle. Here …
proteins, but damage to DNA remains uncertain, as does any effect on cell cycle. Here …