Apoptosis is a form of programmed cell death that is regulated by the balance between
prosurvival and proapoptotic BCL-2 protein family members. Evasion of apoptosis is a …

Cell death escape is one of the most prominent features of tumor cells and closely linked to
the dysregulation of members of the Bcl-2 family of proteins. Among those, the anti-apoptotic …

Extracellular signal-related kinases 1 and 2 (ERK1/2) are the final components of the
mitogen-activated protein kinase (MAPK) phosphorylation cascade, an integral module in a …

In June 2022, the FDA granted Accelerated Approval to the BRAF inhibitor dabrafenib in
combination with the MEK inhibitor trametinib for the treatment of adult and paediatric …

Simple Summary Patients with advanced melanoma are often treated with v-raf murine
sarcoma viral oncogene homolog B1 (BRAF) inhibitors. Although these agents prolong life …

Decades of research into the molecular mechanisms of cancer and the development of
novel therapeutics have yielded a number of remarkable successes. However, our ability to …

Evading apoptosis has been linked to tumor development and chemoresistance. One
mechanism for this evasion is the overexpression of prosurvival B-cell lymphoma-2 (BCL-2) …

Intrauterine adhesions (IUAs) caused by mechanical damage or infection increase the risk of
infertility in women. Although numerous physical barriers such as balloon or hydrogel are …

Myeloid cell leukemia 1 (Mcl-1) is a key regulator of the intrinsic apoptosis pathway.
Overexpression of Mcl-1 is correlated with high tumor grade, poor survival, and both intrinsic …

During apoptosis, mitochondrial outer membrane permeabilization (MOMP) enables certain
mitochondrial matrix macromolecules to escape into the cytosol. However, the fate of …