Multiscale simulations of biological membranes: the challenge to understand biological phenomena in a living substance
Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …
composition and structure, functional over a wide range of time scales, and characterized by …
Membrane changes under oxidative stress: the impact of oxidized lipids
Studying photosensitized oxidation of unsaturated phospholipids is of importance for
understanding the basic processes underlying photodynamic therapy, photoaging and many …
understanding the basic processes underlying photodynamic therapy, photoaging and many …
Effect of lipid peroxidation on membrane permeability of cancer and normal cells subjected to oxidative stress
We performed molecular dynamics simulations to investigate the effect of lipid peroxidation
products on the structural and dynamic properties of the cell membrane. Our simulations …
products on the structural and dynamic properties of the cell membrane. Our simulations …
Oxidized phosphatidylcholines in membrane‐level cellular signaling: from biophysics to physiology and molecular pathology
R Volinsky, PKJ Kinnunen - The FEBS journal, 2013 - Wiley Online Library
The oxidation of lipids has been shown to impact virtually all cellular processes. The
paradigm has been that this involvement is due to interference with the functions of …
paradigm has been that this involvement is due to interference with the functions of …
Bilayer deformation, pores, and micellation induced by oxidized lipids
P Boonnoy, V Jarerattanachat… - The journal of …, 2015 - ACS Publications
The influence of different oxidized lipids on lipid bilayers was investigated with 16 individual
1 μs atomistic molecular dynamics (MD) simulations. Binary mixtures of lipid bilayers of 1 …
1 μs atomistic molecular dynamics (MD) simulations. Binary mixtures of lipid bilayers of 1 …
Understanding membrane remodelling initiated by photosensitized lipid oxidation
In this review, we describe how photooxidation changes membrane properties that can
ultimately lead to permanent membrane damage. Lipid photooxidation occurs in the …
ultimately lead to permanent membrane damage. Lipid photooxidation occurs in the …
[HTML][HTML] Biophysics of lipid bilayers containing oxidatively modified phospholipids: insights from fluorescence and EPR experiments and from MD simulations
This review focuses on the influence of oxidized phosphatidylcholines (oxPCs) on the
biophysical properties of model membranes and is limited to fluorescence, EPR, and MD …
biophysical properties of model membranes and is limited to fluorescence, EPR, and MD …
[HTML][HTML] Contrasting roles of oxidized lipids in modulating membrane microdomains
Lipid rafts display a lateral heterogeneity forming membrane microdomains that hold a
fundamental role on biological membranes and are indispensable to physiological functions …
fundamental role on biological membranes and are indispensable to physiological functions …
Membrane damage efficiency of phenothiazinium photosensitizers
Abstract Structure–activity relationships have been widely reported for porphyrin and
phthalocyanine photosensitizers, but not for phenothiazinium derivatives. Here, four …
phthalocyanine photosensitizers, but not for phenothiazinium derivatives. Here, four …
Oxidation changes physical properties of phospholipid bilayers: fluorescence spectroscopy and molecular simulations
Physical properties of oxidized phospholipid (OxPL) membranes consisting of binary
mixtures of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 10 mol% of one …
mixtures of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 10 mol% of one …