Mendelian randomization analyses in ocular disease: a powerful approach to causal inference with human genetic data
J Li, C Li, Y Huang, P Guan, D Huang, H Yu… - Journal of Translational …, 2022 - Springer
Ophthalmic epidemiology is concerned with the prevalence, distribution and other factors
relating to human eye disease. While observational studies cannot avoid confounding …
relating to human eye disease. While observational studies cannot avoid confounding …
New insight of metabolomics in ocular diseases in the context of 3P medicine
Q Zhang, N Wang, Y Rui, Y **a, S **ong, X **a - EPMA Journal, 2023 - Springer
Metabolomics refers to the high-through untargeted or targeted screening of metabolites in
biofluids, cells, and tissues. Metabolome reflects the functional states of cells and organs of …
biofluids, cells, and tissues. Metabolome reflects the functional states of cells and organs of …
Association of gut microbiota with age-related macular degeneration and glaucoma: a bidirectional Mendelian randomization study
C Li, P Lu - Nutrients, 2023 - mdpi.com
The objective of this study was to examine the correlation between gut microbiota and both
age-related macular degeneration (AMD) and glaucoma. Mendelian randomization studies …
age-related macular degeneration (AMD) and glaucoma. Mendelian randomization studies …
Glaucomatous aqueous humor vesicles are smaller and differ in composition compared to controls
Cells communicate with each other using vesicles of varying sizes, including a specific
repertoire known as exosomes. We isolated aqueous humor (AH)-derived vesicles using …
repertoire known as exosomes. We isolated aqueous humor (AH)-derived vesicles using …
Untargeted and Oxylipin-Targeted Metabolomics Study on the Plasma Samples of Primary Open-Angle Glaucoma Patients
J Xu, C Fu, Y Sun, X Wen, CB Chen, C Huang, TK Ng… - Biomolecules, 2024 - mdpi.com
Purpose: to determine the metabolomics profiles in the plasma samples of primary open-
angle glaucoma (POAG) patients. Methods: The plasma samples from 20 POAG patients …
angle glaucoma (POAG) patients. Methods: The plasma samples from 20 POAG patients …
[HTML][HTML] Oxylipins in aqueous humor of primary open-angle glaucoma patients
J Xu, K Zhou, C Fu, CB Chen, Y Sun, X Wen, L Yang… - Biomolecules, 2024 - mdpi.com
Purpose: Investigate the oxylipin profiles in the aqueous humor of primary open-angle
glaucoma (POAG) patients. Methods: Aqueous humor samples were collected from 17 …
glaucoma (POAG) patients. Methods: Aqueous humor samples were collected from 17 …
Genetic association of lipid traits and lipid-related drug targets with normal tension glaucoma: a Mendelian randomization study for predictive preventive and …
T Kang, Y Zhou, C Fan, Y Zhang, Y Yang, J Jiang - EPMA Journal, 2024 - Springer
Background Glaucoma is the leading cause of irreversible blindness worldwide. Normal
tension glaucoma (NTG) is a distinct subtype characterized by intraocular pressures (IOP) …
tension glaucoma (NTG) is a distinct subtype characterized by intraocular pressures (IOP) …
Shedding light on eye disease in obesity: A review
S Lam, J Lindsey, BG Carranza Leon… - Clinical …, 2024 - Wiley Online Library
Obesity is known to be associated with numerous ocular manifestations, including but not
limited to, diabetic retinopathy (DR), age‐related macular degeneration (AMD), cataracts …
limited to, diabetic retinopathy (DR), age‐related macular degeneration (AMD), cataracts …
[HTML][HTML] Understanding the complex genetics and molecular mechanisms underlying glaucoma
W Wang, H Wang - Molecular Aspects of Medicine, 2023 - Elsevier
Glaucoma is the leading cause of irreversible blindness worldwide. Currently the only
effective treatment for glaucoma is to reduce the intraocular pressure, which can halt the …
effective treatment for glaucoma is to reduce the intraocular pressure, which can halt the …
Application of mendelian randomization in ocular diseases: a review
X Zhang, W Yuan, J Xu, F Zhao - Human Genomics, 2024 - Springer
Ocular disorders can significantly lower patients' quality of life and impose an economic
burden on families and society. However, for the majority of these diseases, their prevalence …
burden on families and society. However, for the majority of these diseases, their prevalence …