DNA hypomethylation was the initial epigenetic abnormality recognized in human tumors.
However, for several decades after its independent discovery by two laboratories in 1983, it …

The field of cancer epigenetics is evolving rapidly on several fronts. Advances in our
understanding of chromatin structure, histone modification, transcriptional activity and DNA …

Background Despite optimal and early surgical treatment of non–small-cell lung cancer
(NSCLC), many patients die of recurrent NSCLC. We investigated the association between …

The aim of the present study was to perform a systematic review of published studies to
provide a robust estimation of the use of procalcitonin (ProCT) as a diagnostic marker of …

Background DNA hypermethylation events and other epimutations occur in many
neoplasms, producing gene expression changes that contribute to neoplastic …

The term epigenetics defines a heritable alteration in gene expression without an
accompanying change in primary DNA sequence. Two major mechanisms that foster …

If detected early, breast cancer is eminently curable. To detect breast cancer in samples with
little cellularity, a high level of sensitivity is needed. Tumor-specific promoter …

A biomarker is a molecular target analyzed in a qualitative or quantitative manner to detect
and diagnose the presence of a disease, to predict the outcome and the response to a …

Such as a carcinoma, sarcoma or leukemia, associated with hypermethylation of genes by
isolating the genes from tissue containing as few as 50 to 1000 tumor cells. Using quantita …

Epithelial–mesenchymal transition (EMT) is vital for morphogenesis during embryonic
development and is also critical for the conversion of early stage tumors into invasive …