Ten-eleven translocation (TET) proteins are iron-dependent and α-ketoglutarate-dependent
dioxygenases that sequentially oxidize the methyl group of 5-methylcytosine (5mC) to 5 …

Various cellular stress conditions trigger mitochondrial DNA (mtDNA) release from
mitochondria into the cytosol. The released mtDNA is sensed by the cGAS-MITA/STING …

Age is a major risk factor for cancer, but how aging impacts tumor control remains unclear. In
this study, we establish that aging of the immune system, regardless of the age of the stroma …

Clonal hematopoiesis of indeterminate potential (CHIP) is defined by the presence of a
cancer-associated somatic mutation in white blood cells in the absence of overt …

Clonal hematopoiesis (CH) increases inflammasome-linked atherosclerosis, but the
mechanisms by which CH mutant cells transmit inflammatory signals to nonmutant cells are …

Myeloid malignancies are devastating hematologic cancers with limited therapeutic options.
Inflammation is emerging as a novel driver of myeloid malignancy, with important …

Acquired genetic or cytogenetic alterations in a blood stem cell that confer clonal fitness
promote its relative expansion leading to clonal hematopoiesis (CH). Despite a largely intact …

Mitochondria are cellular organelles which generate adenosine triphosphate (ATP)
molecules for the maintenance of cellular energy through the oxidative phosphorylation …

Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease. The
pathogenesis of DKD is multifactorial, with several molecular pathways implicated. Recent …

Somatic loss-of-function mutations of the dioxygenase Ten-eleven translocation-2 (TET2)
occur frequently in individuals with clonal hematopoiesis (CH) and acute myeloid leukemia …