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Mechanical state transitions in the regulation of tissue form and function
From embryonic development, postnatal growth and adult homeostasis to reparative and
disease states, cells and tissues undergo constant changes in genome activity, cell fate …
disease states, cells and tissues undergo constant changes in genome activity, cell fate …
Mechanisms of 3D cell migration
Cell migration is essential for physiological processes as diverse as development, immune
defence and wound healing. It is also a hallmark of cancer malignancy. Thousands of …
defence and wound healing. It is also a hallmark of cancer malignancy. Thousands of …
Cell–cell adhesion and 3D matrix confinement determine jamming transitions in breast cancer invasion
Plasticity of cancer invasion and metastasis depends on the ability of cancer cells to switch
between collective and single-cell dissemination, controlled by cadherin-mediated cell–cell …
between collective and single-cell dissemination, controlled by cadherin-mediated cell–cell …
Physical models of collective cell migration
Collective cell migration is a key driver of embryonic development, wound healing, and
some types of cancer invasion. Here, we provide a physical perspective of the mechanisms …
some types of cancer invasion. Here, we provide a physical perspective of the mechanisms …
Mechanobiology of collective cell behaviours
The way in which cells coordinate their behaviours during various biological processes,
including morphogenesis, cancer progression and tissue remodelling, largely depends on …
including morphogenesis, cancer progression and tissue remodelling, largely depends on …
Cancer cell motility: lessons from migration in confined spaces
Time-lapse, deep-tissue imaging made possible by advances in intravital microscopy has
demonstrated the importance of tumour cell migration through confining tracks in vivo. These …
demonstrated the importance of tumour cell migration through confining tracks in vivo. These …
Motility-driven glass and jamming transitions in biological tissues
Cell motion inside dense tissues governs many biological processes, including embryonic
development and cancer metastasis, and recent experiments suggest that these tissues …
development and cancer metastasis, and recent experiments suggest that these tissues …
The 2020 motile active matter roadmap
Activity and autonomous motion are fundamental in living and engineering systems. This
has stimulated the new field of'active matter'in recent years, which focuses on the physical …
has stimulated the new field of'active matter'in recent years, which focuses on the physical …
Response of cells and tissues to shear stress
Shear stress is essential for normal physiology and malignancy. Common physiological
processes–such as blood flow, particle flow in the gut, or contact between migratory cell …
processes–such as blood flow, particle flow in the gut, or contact between migratory cell …
In primary airway epithelial cells, the unjamming transition is distinct from the epithelial-to-mesenchymal transition
The epithelial-to-mesenchymal transition (EMT) and the unjamming transition (UJT) each
comprises a gateway to cellular migration, plasticity and remodeling, but the extent to which …
comprises a gateway to cellular migration, plasticity and remodeling, but the extent to which …