The main objective of this paper is to develop closed-loop therapeutic systems by reviewing
various neurological disorders. We propose a system that incorporates a biosensor …

Simple Summary Cancer is among the leading causes of death, and cancer therapy suffers
from many drawbacks, the lack of selectivity being most noteworthy. In this review, we …

Small molecules that interfere with microtubule dynamics, such as Taxol and the Vinca
alkaloids, are widely used in cell biology research and as clinical anticancer drugs …

Surface charge plays a fundamental role in determining the fate of a nanoparticle, and any
encapsulated contents, in vivo. Herein, we describe, and visualise in real time, light …

Background: Cancer chemotherapy is limited by severe side effects due to unspecific
cytotoxic activity of currently used therapeutics. In order to minimize these unwanted effects …

We present the combination of the clinically well-proven chemotherapeutic agent,
Doxorubicin, and 99mTc, an Auger and internal conversion electron emitter, into a dual …

Antibody therapeutics show great potential to treat a variety of diseases. Often, the dose that
can be safely administered is limited by side effects that arise from the interaction with the …

The antitumoral activity of hydroxymethylene bisphosphonates (HMBP) such as alendronate
or zoledronate is hampered by their exceptional bone-binding properties and their short …

The synthesis of photoswitchable azo-dibenzo [b, f] oxepine derivatives and microtubule
inhibitors were described. Subsequently, we examined the reaction of methoxy derivative 3 …

Abstract Channelrhodopsin-2 (ChR2) has become a celebrated research tool and is
considered a promising potential therapeutic for neurological disorders. While making its …