Mechanisms and regulation of cholesterol homeostasis
Cholesterol homeostasis is vital for proper cellular and systemic functions. Disturbed
cholesterol balance underlies not only cardiovascular disease but also an increasing …
cholesterol balance underlies not only cardiovascular disease but also an increasing …
[PDF][PDF] Role of cholesterol‐associated steatohepatitis in the development of NASH
CL Horn, AL Morales, C Savard… - Hepatology …, 2022 - Wiley Online Library
The rising prevalence of nonalcoholic fatty liver disease (NAFLD) and NAFLD‐related
cirrhosis in the United States and globally highlights the need to better understand the …
cirrhosis in the United States and globally highlights the need to better understand the …
Hepatic cholesterol transport and its role in non-alcoholic fatty liver disease and atherosclerosis
H Li, XH Yu, X Ou, XP Ouyang, CK Tang - Progress in lipid research, 2021 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is a quickly emerging global health problem
representing the most common chronic liver disease in the world. Atherosclerotic …
representing the most common chronic liver disease in the world. Atherosclerotic …
Acyl-coenzyme A: cholesterol acyltransferases
The enzymes acyl-coenzyme A (CoA): cholesterol acyltransferases (ACATs) are membrane-
bound proteins that utilize long-chain fatty acyl-CoA and cholesterol as substrates to form …
bound proteins that utilize long-chain fatty acyl-CoA and cholesterol as substrates to form …
Cholesterol metabolic reprogramming in cancer and its pharmacological modulation as therapeutic strategy
I Giacomini, F Gianfanti, MA Desbats, G Orso… - Frontiers in …, 2021 - frontiersin.org
Cholesterol is a ubiquitous sterol with many biological functions, which are crucial for proper
cellular signaling and physiology. Indeed, cholesterol is essential in maintaining membrane …
cellular signaling and physiology. Indeed, cholesterol is essential in maintaining membrane …
Multiple functions of microsomal triglyceride transfer protein
Microsomal triglyceride transfer protein (MTP) was first identified as a major cellular protein
capable of transferring neutral lipids between membrane vesicles. Its role as an essential …
capable of transferring neutral lipids between membrane vesicles. Its role as an essential …
Roles of acyl-coenzyme A: cholesterol acyltransferase-1 and-2
Acyl-coenzyme A: cholesterol acyltransferase (ACAT) is an intracellular enzyme that
produces cholesteryl esters in various tissues. In mammals, two ACAT genes (ACAT1 and …
produces cholesteryl esters in various tissues. In mammals, two ACAT genes (ACAT1 and …
Acyl coenzyme A: cholesterol acyltransferase types 1 and 2: structure and function in atherosclerosis
LL Rudel, RG Lee, TL Cockman - Current opinion in lipidology, 2001 - journals.lww.com
Two enzymes are responsible for cholesterol ester formation in tissues, acyl coenzyme A:
cholesterol acyltransferase types 1 and 2 (ACAT1 and ACAT2). The available evidence …
cholesterol acyltransferase types 1 and 2 (ACAT1 and ACAT2). The available evidence …
Differential expression of ACAT1 and ACAT2 among cells within liver, intestine, kidney, and adrenal of nonhuman primates
RG Lee, MC Willingham, MA Davis, KA Skinner… - Journal of lipid …, 2000 - ASBMB
Two closely related enzymes with more than 50% sequence identity have been identified
that catalyze the esterification of cholesterol using acyl-CoA substrates, namely acyl-CoA …
that catalyze the esterification of cholesterol using acyl-CoA substrates, namely acyl-CoA …
The enzymes of neutral lipid synthesis
From the‡ Gladstone Institute of Cardiovascular Disease, San Francisco, California 94141-
9100 and the § Cardiovascular Research Institute and¶ Department of Medicine, University …
9100 and the § Cardiovascular Research Institute and¶ Department of Medicine, University …