[HTML][HTML] The potential of human peptide LL-37 as an antimicrobial and anti-biofilm agent

KE Ridyard, J Overhage - Antibiotics, 2021 - mdpi.com
The rise in antimicrobial resistant bacteria threatens the current methods utilized to treat
bacterial infections. The development of novel therapeutic agents is crucial in avoiding a …

Antimicrobial peptide structure and mechanism of action: a focus on the role of membrane structure

TH Lee, KN Hall, MI Aguilar - Current topics in medicinal …, 2016 - ingentaconnect.com
Antimicrobial peptides (AMPs) are showing increasing promise as potential candidate
antibacterial drugs in the face of the rapidly emerging bacterial resistance to conventional …

[HTML][HTML] Population-level metagenomics uncovers distinct effects of multiple medications on the human gut microbiome

N Nagata, S Nishijima, T Miyoshi-Akiyama, Y Kojima… - Gastroenterology, 2022 - Elsevier
Background & aims Medication is a major determinant of human gut microbiome structure,
and its overuse increases the risks of morbidity and mortality. However, effects of certain …

Application of antimicrobial peptides of the innate immune system in combination with conventional antibiotics—a novel way to combat antibiotic resistance?

MS Zharkova, DS Orlov, OY Golubeva… - Frontiers in cellular …, 2019 - frontiersin.org
Rapidly growing resistance of pathogenic bacteria to conventional antibiotics leads to
inefficiency of traditional approaches of countering infections and determines the urgent …

Synergistic action of antimicrobial peptides and antibiotics: Current understanding and future directions

S Taheri-Araghi - Frontiers in Microbiology, 2024 - frontiersin.org
Antibiotic resistance is a growing global problem that requires innovative therapeutic
approaches and strategies for administering antibiotics. One promising approach is …

Bacterial strategies of resistance to antimicrobial peptides

HS Joo, CI Fu, M Otto - … of the Royal Society B: Biological …, 2016 - royalsocietypublishing.org
Antimicrobial peptides (AMPs) are a key component of the host's innate immune system,
targeting invasive and colonizing bacteria. For successful survival and colonization of the …

Fundamentals on the molecular mechanism of action of antimicrobial peptides

JAF Corrêa, AG Evangelista, T de Melo Nazareth… - Materialia, 2019 - Elsevier
Antimicrobial peptides (AMPs) are produced by several organisms as their first line of
defense. Constituted by amino acids, they may present different mechanisms of action. The …

Impacts of municipal wastewater treatment plant discharge on microbial community structure and function of the receiving river in Northwest Tibetan Plateau

J Wang, Y Chen, P Cai, Q Gao, H Zhong, W Sun… - Journal of Hazardous …, 2022 - Elsevier
Wastewater treatment plant (WWTP) effluents carrying plenty of nutrients and
micropollutants pose serious threats to receiving rivers, however, the response of microbial …

The role of bacterial lipid diversity and membrane properties in modulating antimicrobial peptide activity and drug resistance

TH Lee, V Hofferek, F Separovic, GE Reid… - Current opinion in …, 2019 - Elsevier
This review provides an analysis of the role that membrane composition and structure plays
in the resistance of microorganisms to antimicrobial peptides (AMPs). We describe the …

Potential applications of antimicrobial peptides and their mimics in combating caries and pulpal infections

S Mai, MT Mauger, L Niu, JB Barnes, S Kao… - Acta Biomaterialia, 2017 - Elsevier
Antimicrobial peptides (AMPs) are short cationic host-defense molecules that provide the
early stage of protection against invading microbes. They also have important modulatory …