Infrared ion spectroscopy: New opportunities for small-molecule identification in mass spectrometry-A tutorial perspective

J Martens, RE van Outersterp, RJ Vreeken… - Analytica chimica …, 2020 - Elsevier
Combining the individual analytical strengths of mass spectrometry and infrared
spectroscopy, infrared ion spectroscopy is increasingly recognized as a powerful tool for …

Unraveling the unknown areas of the human metabolome: the role of infrared ion spectroscopy

J Martens, G Berden, H Bentlage, KLM Coene… - Journal of Inherited …, 2018 - Springer
The identification of molecular biomarkers is critical for diagnosing and treating patients and
for establishing a fundamental understanding of the pathophysiology and underlying …

Structural identification of electron transfer dissociation products in mass spectrometry using infrared ion spectroscopy

J Martens, J Grzetic, G Berden, J Oomens - Nature Communications, 2016 - nature.com
Tandem mass spectrometry occupies a principle place among modern analytical methods
and drives many developments in the 'omics' sciences. Electron attachment induced …

Evidence of Diketopiperazine and Oxazolone Structures for HA b2+ Ion

BR Perkins, J Chamot-Rooke, SH Yoon… - Journal of the …, 2009 - ACS Publications
Peptide fragmentation can lead to an oxazolone or diketopiperazine b2+ ion structure.
IRMPD spectroscopy combined with computational modeling and gas-phase H/D exchange …

Effect of Peptide Fragment Size on the Propensity of Cyclization in Collision-Induced Dissociation: Oligoglycine b2−b8

X Chen, L Yu, JD Steill, J Oomens… - Journal of the American …, 2009 - ACS Publications
The chemistry of peptide fragmentation by collision-induced dissociation (CID) is currently
being reviewed, as a result of observations that the amino acid sequence of peptide …

Cyclization and Rearrangement Reactions of an Fragment Ions of Protonated Peptides

BJ Bythell, P Maître, B Paizs - Journal of the American Chemical …, 2010 - ACS Publications
an ions are frequently formed in collision-induced dissociation (CID) of protonated peptides
in tandem mass spectrometry (MS/MS) based sequencing experiments. These ions have …

Infrared Spectroscopy of Fragments of Protonated Peptides: Direct Evidence for Macrocyclic Structures of b5 Ions

U Erlekam, BJ Bythell, D Scuderi… - Journal of the …, 2009 - ACS Publications
b ions are of fundamental importance in peptide sequencing using tandem mass
spectrometry. These ions have generally been assumed to exist as protonated oxazolone …

Towards understanding the tandem mass spectra of protonated oligopeptides. 2: The proline effect in collision-induced dissociation of protonated Ala-Ala-Xxx-Pro-Ala …

C Bleiholder, S Suhai, AG Harrison… - Journal of the American …, 2011 - ACS Publications
The product ion spectra of proline-containing peptides are commonly dominated by yn ions
generated by cleavage at the N-terminal side of proline residues. This proline effect is …

Molecular hydrogen messengers can lead to structural infidelity: A cautionary tale of protonated glycine

A Masson, ER Williams, TR Rizzo - The Journal of chemical physics, 2015 - pubs.aip.org
The effects of tagging protonated glycine with either He or between 1 and 14 H 2 molecules
on the infrared photodissociation spectra and the ion structure were investigated …

Gas-phase structure and fragmentation pathways of singly protonated peptides with N-terminal arginine

BJ Bythell, IP Csonka, S Suhai… - The Journal of …, 2010 - ACS Publications
The gas-phase structures and fragmentation pathways of the singly protonated peptide
arginylglycylaspartic acid (RGD) are investigated by means of collision-induced-dissociation …