Here we review some properties and functions of backpropagating action potentials in the
dendrites of mammalian CNS neurones. We focus on three main aspects: firstly the current …

Scientific models are abstractions that aim to explain natural phenomena. A successful
model shows how a complex phenomenon arises from relatively simple principles while …

The recurrent excitatory and inhibitory connections between and within layers of the cerebral
cortex are fundamental to the operation of local cortical circuits. Models of cortical function …

Mammalian sperm are unable to fertilize the egg immediately after ejaculation; they acquire
this capacity during migration in the female reproductive tract. This maturational process is …

The patch-clamp technique allows investigation of the electrical excitability of neurons and
the functional properties and densities of ion channels. Most patch-clamp recordings from …

Biophysically accurate multicompartmental models of individual neurons have significantly
advanced our understanding of the input–output function of single cells. These models …

The voltage-clamp technique is applicable only to spherical cells. In nonspherical cells, such
as neurons, the membrane potential is not clamped distal to the voltage-clamp electrode …

Although neurons are known to exhibit a broad array of intrinsic properties that impact
critically on the computations they perform, very few studies have quantified such …

Abnormal neuronal excitability and impaired synaptic plasticity might occur before the
degeneration and death of neurons in Alzheimer's disease (AD). To elucidate potential …

The voltage clamp technique is frequently used to examine the strength and composition of
synaptic input to neurons. Even accounting for imperfect voltage control of the entire cell …