The RNA interference (RNAi) pathway regulates mRNA stability and translation in nearly all
human cells. Small double-stranded RNA molecules can efficiently trigger RNAi silencing of …

The first published description of therapeutic applications of antisense oligonucleotide
(ASO) technology occurred in the late 1970s and was followed by the founding of …

One hallmark of trivalent N-acetylgalactosamine (GalNAc)-conjugated siRNAs is the
remarkable durability of silencing that can persist for months in preclinical species and …

Exosomes are small vesicles that are secreted from metazoan cells and may convey
selected membrane proteins and small RNAs to target cells for the control of cell migration …

2. INTRODUCTION The investigation of many fundamental processes in life sciences
requires straightforward tools for fast, sensitive, reliable, and reproducible detection of …

RNA interference (RNAi) is the mechanism through which double-stranded RNAs silence
cognate genes,,,,. In plants, this can occur at both the transcriptional and the post …

MicroRNAs (miRNAs) interact with target mRNAs at specific sites to induce cleavage of the
message or inhibit translation. The specific function of most mammalian miRNAs is …

A conserved biological response to double-stranded RNA, known variously as RNA
interference (RNAi) or post-transcriptional gene silencing, mediates resistance to both …

Two small RNAs regulate the timing of Caenorhabditis elegans development,. Transition
from the first to the second larval stage fates requires the 22-nucleotide lin-4 RNA,,, and …

Small interfering RNAs (siRNAs) are widely used to study gene function owing to the ease
with which they silence target genes, and there is considerable interest in their potential for …