Despite two decades of intensified research to understand and cure tuberculosis disease,
biological uncertainties remain and hamper progress. However, owing to collaborative …

Over the past 2000 years, tuberculosis (TB) has claimed more lives than any other infectious
disease. In 2020 alone, TB was responsible for 1.5 million deaths worldwide, comparable to …

Background The bedaquiline–pretomanid–linezolid regimen has been reported to have
90% efficacy against highly drug-resistant tuberculosis, but the incidence of adverse events …

Sulfoximines have been largely disregarded in medicinal chemistry for a long time.
However, recently, they have risen to the apparent level of stardom on the drug discovery …

In the last two decades, multi (MDR), extensively (XDR), extremely (XXDR) and total (TDR)
drug-resistant Mycobacterium tuberculosis (M. tb) strains have emerged as a threat to public …

Rationale: Improving treatment outcomes while reducing drug toxicity and shortening the
treatment duration to∼ 6 months remains an aspirational goal for the treatment of multidrug …

As a family of cationic host defense peptides, defensins are mainly synthesized by Paneth
cells, neutrophils, and epithelial cells, contributing to host defense. Their biological functions …

Drug-resistant tuberculosis is a substantial health-care concern worldwide. Despite culture-
based methods being considered the gold standard for drug susceptibility testing, molecular …

There is an urgent need for new, potent antituberculosis (anti-TB) drugs with novel
mechanisms of action that can be included in new regimens to shorten the treatment period …

Mycobacterium tuberculosis (MTB), the causative agent of tuberculosis, stands as an
immensely devastating and persistently relevant pathogen, claiming the lives of millions …