Cell-based therapies are being developed for various neurodegenerative diseases that
affect the central nervous system (CNS). Concomitantly, the roles of individual cell types in …

Osteopontin (OPN) also known by its official gene designation secreted phosphoprotein‐1
(SPP1) is a fascinating, multifunctional protein expressed in a number of cell types that …

Cell replacement therapies for Parkinson's disease (PD) based on transplantation of
pluripotent stem cell-derived dopaminergic neurons are now entering clinical trials. Here, we …

The specific loss of midbrain dopamine neurons (mDANs) causes major motor dysfunction
in Parkinson's disease, which makes cell replacement a promising therapeutic approach …

The maturation of human pluripotent stem cell (hPSC)-derived neurons mimics the
protracted timing of human brain development, extending over months to years for reaching …

Blood-brain barrier (BBB) function deteriorates during aging, contributing to cognitive
impairment and neurodegeneration. It is unclear what drives BBB leakage in aging and how …

Parkinson's disease is characterized by the loss of dopaminergic neurons in the substantia
nigra leading to disabling deficits. Dopamine neuron grafts may provide a significant …

Human pluripotent stem cells show considerable promise for applications in regenerative
medicine, including the development of cell replacement paradigms for the treatment of …

Mesial temporal lobe epilepsy (MTLE) is the most common focal epilepsy. One-third of
patients have drug-refractory seizures and are left with suboptimal therapeutic options such …

Three-dimensional brain organoids have emerged as a valuable model system for studies of
human brain development and pathology. Here we establish a midbrain organoid culture …