Inhibin at 90: from discovery to clinical application, a historical review

Y Makanji, J Zhu, R Mishra, C Holmquist… - Endocrine …, 2014 - academic.oup.com
When it was initially discovered in 1923, inhibin was characterized as a hypophysiotropic
hormone that acts on pituitary cells to regulate pituitary hormone secretion. Ninety years …

Pre‐eclampsia: fitting together the placental, immune and cardiovascular pieces

JL James, GS Whitley, JE Cartwright - The Journal of pathology, 2010 - Wiley Online Library
The success of pregnancy is a result of countless ongoing interactions between the placenta
and the maternal immune and cardiovascular systems. Pre‐eclampsia is a serious …

INHA promoter polymorphisms are associated with premature ovarian failure

SE Harris, AL Chand, IM Winship… - Molecular human …, 2005 - academic.oup.com
Inhibin is an important glycoprotein that is involved in folliculogenesis. INHA, the gene
encoding the inhibin alpha subunit, was recently proposed as a candidate for premature …

Association analysis of the INHA gene with litter size in Boer goats

W Wu, G Hua, L Yang, Q Wen, C Zhang… - Small Ruminant …, 2009 - Elsevier
This study investigated the association between differences in litter size in Boer does, with
genetic polymorphisms in the inhibin alpha gene. Our preliminary (n= 209) results found 12 …

Epigenetic regulation of inhibin alpha-subunit gene in prostate cancer cell lines

P Balanathan, EM Ball, H Wang… - Journal of …, 2004 - jme.bioscientifica.com
Androgens promote anabolism in the musculoskeletal system while generally repressing
adiposity, leading to lean body composition. Circulating androgens decline with age …

Exploring polymorphisms and their effects on reproductive traits of the INHA and INHβA genes in three goat breeds

J Hou, X An, G Li, Y Wang, Y Song… - Animal Science …, 2012 - Wiley Online Library
In this study, we report the analysis of INHA and INHβA gene polymorphisms in 786 goats of
three breeds: **nong Saanen (SN), Guanzhong (GZ) and Boer (BG). We identified three new …

Reversible effects of oxygen partial pressure on genes associated with placental angiogenesis and differentiation in primary‐term cytotrophoblast cell culture

F Debiève, C Depoix, D Gruson… - Molecular …, 2013 - Wiley Online Library
Timely regulated changes in oxygen partial pressure are important for placental formation.
Disturbances could be responsible for pregnancy‐related diseases like preeclampsia and …

Predicting combinatorial binding of transcription factors to regulatory elements in the human genome by association rule mining

XC Morgan, S Ni, DP Miranker, VR Iyer - BMC bioinformatics, 2007 - Springer
Background Cis-acting transcriptional regulatory elements in mammalian genomes typically
contain specific combinations of binding sites for various transcription factors. Although …

Inhibin alpha gene expression in human trophoblasts is regulated by interactions between TFAP2 and cAMP signaling pathways

CL Depoix, F Debiève… - Molecular Reproduction …, 2014 - Wiley Online Library
Inhibin α (Inha) gene expression is regulated, in rat granulosa cells, via a cyclic 3′, 5′‐
adenosine monophosphate (AMP)‐response element (CRE) found in a region of the …

HIF1A and EPAS1 mRNA and protein expression during in vitro culture of human primary term cytotrophoblasts and effect of oxygen tension on their expression

CL Depoix, O Flabat, F Debiève, C Hubinont - Reproductive Biology, 2016 - Elsevier
During the first trimester of pregnancy, placenta formation probably occurs in a low-oxygen
environment necessary to protect cytotrophoblasts from oxidative stress and to allow proper …