Histone variants endow chromatin with unique properties and show a specific genomic
distribution that is regulated by specific deposition and removal machineries. These variants …

In eukaryotes, DNA is organized together with histones and non-histone proteins into a
highly complex nucleoprotein structure called chromatin, with the nucleosome as its …

Recent developments indicate that macrodomains, an ancient and diverse protein domain
family, are key players in the recognition, interpretation, and turnover of ADP-ribose (ADPr) …

▪ Abstract Dosage compensation in mammals is achieved by the transcriptional inactivation
of one X chromosome in female cells. From the time X chromosome inactivation was initially …

This protocol is an extension to: Nat. Protoc. 6, 870–895 (2014); doi: 10.1038/nprot.
2011.328; published online 02 June 2011 Cycling cells duplicate their DNA content during S …

Histones are fundamental structural components of chromatin. Eukaryotic DNA is wound
around an octamer of the core histones H2A, H2B, H3, and H4. Binding of linker histone H1 …

One of the most dramatic chromatin remodelling processes takes place during mammalian
spermatogenesis. Indeed, during the postmeiotic maturation of male haploid germ cells, or …

Chromatin on the mammalian inactive X chromosome differs in a number of ways from that
on the active X. One protein, macroH2A, whose amino terminus is closely related to histone …

MacroH2A1 is a histone variant that is enriched on the inactive X chromosome (**) in
mammals and is postulated to play an important, but unknown, role in the repression of gene …

MacroH2A1 is an unusual variant of the core histone H2A which is enriched in chromatin on
the inactive X chromosome of female mammals. The N-terminal third of the protein shares …