Macropinocytosis is a regulated form of endocytosis that mediates the non‐selective uptake
of solute molecules, nutrients and antigens. It is an actin‐dependent process initiated from …

The ingestion of particles or cells by phagocytosis and of fluids by macropinocytosis requires
the formation of large endocytic vacuolar compartments inside cells by the organized …

Salmonellae are important causes of enteric diseases in all vertebrates. Characterization of
the molecular mechanisms that underpin the interactions of salmonellae with their animal …

Guanine nucleotide exchange factors (RhoGEFs) and GTPase-activating proteins
(RhoGAPs) coordinate the activation state of the Rho family of GTPases for binding to …

UK Biobank is among the world's largest repositories for phenotypic and genotypic
information in individuals of European ancestry. We performed a genome-wide association …

Macropinocytosis is defined as an actin-dependent but coat-and dynamin-independent
endocytic uptake process, which generates large intracellular vesicles (macropinosomes) …

Translocation of bacteria across the intestinal barrier is important in the pathogenesis of
systemic sepsis, although the mechanisms by which bacterial translocation occurs remain …

Macropinocytosis is an important mechanism of internalizing extracellular materials and
dissolved molecules in eukaryotic cells. Macropinocytosis has a dual effect on cancer cells …

Salmonella enterica, the cause of food poisoning and typhoid fever, has evolved
sophisticated mechanisms to modulate Rho family guanosine triphosphatases (GTPases) to …

Macropinocytosis, a form of bulk uptake of fluid and solid cargo into cytoplasmic vacuoles,
called macropinosomes, has been studied mostly in relation to antigen presentation. Early …