Metastasis remains the greatest challenge in the clinical management of cancer. Cell motility
is a fundamental and ancient cellular behaviour that contributes to metastasis and is …

Despite the decline in death rate from breast cancer and recent advances in targeted
therapies and combinations for the treatment of metastatic disease, metastatic breast cancer …

Members of the ING family of tumor suppressors regulate cell cycle progression, apoptosis,
and DNA repair as important cofactors of p53. ING1 and ING3 are stable components of the …

With a lifetime risk estimated to be one in eight in industrialized countries, breast cancer is
the most frequent type of cancer among women worldwide. Patients are often treated with …

Epigenetic changes can be defined as stable molecular alterations of a cellular phenotype
such as the gene expression profile of a cell that are heritable during somatic cell divisions …

The histone acetyltransferases (HATs) of the MYST family are highly conserved in
eukaryotes and carry out a significant proportion of all nuclear acetylation. These enzymes …

Breast cancer metastasis suppressor 1 (BRMS1) is a predominantly nuclear protein that
differentially regulates expression of multiple genes, leading to suppression of metastasis …

Estrogen is well-established as a mitogenic factor implicated in the tumorigenesis and
progression of breast cancer via its binding to the estrogen receptor α (ERα). Recent data …

At face value, the Sin3 histone deacetylase (HDAC) complex appears to be a prototypical co-
repressor complex, that is, a multi-protein complex recruited to chromatin by DNA bound …

Sin3 was isolated over two decades ago as a negative regulator of transcription in budding
yeast. Subsequent research has established the protein as a master transcriptional scaffold …