[HTML][HTML] Antimicrobial mechanisms and clinical application prospects of antimicrobial peptides

X Li, S Zuo, B Wang, K Zhang, Y Wang - Molecules, 2022 - mdpi.com
Antimicrobial peptides are a type of small-molecule peptide that widely exist in nature and
are components of the innate immunity of almost all living things. They play an important role …

The structure-mechanism relationship and mode of actions of antimicrobial peptides: A review

S Li, Y Wang, Z Xue, Y Jia, R Li, C He… - Trends in Food Science & …, 2021 - Elsevier
Background The rapid increase of drug resistance in conventional antibiotics promotes the
discovery and development of antimicrobial peptides (AMPs), which are important …

Antimicrobial peptides as anti-infective agents in pre-post-antibiotic era?

T Rončević, J Puizina, A Tossi - International journal of molecular …, 2019 - mdpi.com
Resistance to antibiotics is one of the main current threats to human health and every year
multi-drug resistant bacteria are infecting millions of people worldwide, with many dying as a …

Broad-spectrum hybrid antimicrobial peptides derived from PMAP-23 with potential LPS binding ability

Y Lyu, M Tan, M Xue, W Hou, C Yang, A Shan… - Biochemical …, 2023 - Elsevier
Antimicrobial peptides, as an integral part of the innate immune system, kill bacteria through
a special mechanism of action, making them less susceptible to drug resistance. However …

Synergistic antibacterial activity of designed Trp-containing antibacterial peptides in combination with antibiotics against multidrug-resistant Staphylococcus …

D Shang, Y Liu, F Jiang, F Ji, H Wang… - Frontiers in Microbiology, 2019 - frontiersin.org
Multidrug resistance among various bacterial strains is leading to worldwide resistance to a
wide range of antibiotics. Combination therapy involving current antibiotics and other …

[HTML][HTML] Design, engineering and discovery of novel α-helical and β-boomerang antimicrobial peptides against drug resistant bacteria

S Bhattacharjya, SK Straus - International Journal of Molecular Sciences, 2020 - mdpi.com
In an era where the pipeline of new antibiotic development is drying up, the continuous rise
of multi-drug resistant (MDR) and extensively drug resistant (XDR) bacteria are genuine …

Modulating antimicrobial activity and mammalian cell biocompatibility with glucosamine-functionalized star polymers

EHH Wong, MM Khin, V Ravikumar, Z Si… - …, 2016 - ACS Publications
The development of novel reagents and antibiotics for combating multidrug resistance
bacteria has received significant attention in recent years. In this study, new antimicrobial …

Influence of self-assembly on the performance of antimicrobial peptides

SM Häffner, M Malmsten - Current opinion in colloid & interface science, 2018 - Elsevier
Highlights•Factors determining AMP self-assembly discussed.•Effects of AMPs on amyloid
structures outlined.•AMP-based superstructures as functional biomaterials exemplified.•AMP …

Aggregation and its influence on the bioactivities of a novel antimicrobial peptide, temporin-PF, and its analogues

Y Zai, X **, Z Ye, C Ma, M Zhou, X Chen… - International Journal of …, 2021 - mdpi.com
Temporin is an antimicrobial peptide (AMP) family discovered in the skin secretion of ranid
frog that has become a promising alternative for conventional antibiotic therapy. Herein, a …

First-in-class cyclic Temporin L analogue: Design, synthesis, and antimicrobial assessment

R Bellavita, B Casciaro, S Di Maro… - Journal of medicinal …, 2021 - ACS Publications
The pharmacodynamic and pharmacokinetic properties of bioactive peptides can be
modulated by introducing conformational constraints such as intramolecular …