The uptake and metabolism of amino acids, and their unique role in the biology of pathogenic trypanosomatids

L Marchese, JF Nascimento, FS Damasceno… - Pathogens, 2018 - mdpi.com
Trypanosoma brucei, as well as Trypanosoma cruzi and more than 20 species of the genus
Leishmania, form a group of flagellated protists that threaten human health. These …

Immune Evasion Strategies of Trypanosoma brucei within the Mammalian Host: Progression to Pathogenicity

B Stijlemans, G Caljon, J Van Den Abbeele… - Frontiers in …, 2016 - frontiersin.org
The diseases caused by African trypanosomes (AT) are of both medical and veterinary
importance and have adversely influenced the economic development of sub-Saharan …

Dynamic metabolic exchange governs a marine algal-bacterial interaction

E Segev, TP Wyche, KH Kim, J Petersen, C Ellebrandt… - elife, 2016 - elifesciences.org
Emiliania huxleyi is a model coccolithophore micro-alga that generates vast blooms in the
ocean. Bacteria are not considered among the major factors influencing coccolithophore …

A long noncoding RNA promotes parasite differentiation in African trypanosomes

F Guegan, KS Rajan, F Bento, D Pinto-Neves… - Science …, 2022 - science.org
The parasite Trypanosoma brucei causes African slee** sickness that is fatal to patients if
untreated. Parasite differentiation from a replicative slender form into a quiescent stumpy …

An Overview of Trypanosoma brucei Infections: An Intense Host–Parasite Interaction

A Ponte-Sucre - Frontiers in microbiology, 2016 - frontiersin.org
Trypanosoma brucei rhodesiense and T. brucei gambiense, the causative agents of Human
African Trypanosomiasis, are transmitted by tsetse flies. Within the vector, the parasite …

Combatting African animal trypanosomiasis (AAT) in livestock: the potential role of trypanotolerance

M Yaro, KA Munyard, MJ Stear, DM Groth - Veterinary Parasitology, 2016 - Elsevier
Abstract African Animal Trypanosomiasis (AAT) is endemic in at least 37 of the 54 countries
in Africa. It is estimated to cause direct and indirect losses to the livestock production …

Pathogenicity and virulence of African trypanosomes: From laboratory models to clinically relevant hosts

LJ Morrison, PC Steketee, MD Tettey, KR Matthews - Virulence, 2023 - Taylor & Francis
African trypanosomes are vector-borne protozoa, which cause significant human and animal
disease across sub-Saharan Africa, and animal disease across Asia and South America. In …

The Cytological Events and Molecular Control of Life Cycle Development of Trypanosoma brucei in the Mammalian Bloodstream

E Silvester, KR McWilliam, KR Matthews - Pathogens, 2017 - mdpi.com
African trypanosomes cause devastating disease in sub-Saharan Africa in humans and
livestock. The parasite lives extracellularly within the bloodstream of mammalian hosts and …

African trypanosomes

M Cayla, F Rojas, E Silvester, F Venter, KR Matthews - Parasites & vectors, 2019 - Springer
African trypanosomes cause human African trypanosomiasis and animal African
trypanosomiasis. They are transmitted by tsetse flies in sub-Saharan Africa. Although most …

A paradigm shift: The mitoproteomes of procyclic and bloodstream Trypanosoma brucei are comparably complex

A Zíková, Z Verner, A Nenarokova, PAM Michels… - PLoS …, 2017 - journals.plos.org
Trypanosoma brucei is a parasitic protist that causes significant health burden in sub-
Saharan countries endemic for the tsetse fly (Glossina spp.). During the bloodmeal of this …