Importance Burnout is prevalent in physicians and can have a negative influence on
performance, career continuation, and patient care. Existing evidence does not allow clear …

Background Managing stress and having good quality sleep are inter-related factors that are
essential for health, and both factors seem to be affected by physical activity. Although there …

Machine learning methods, combined with large electronic health databases, could enable
a personalised approach to medicine through improved diagnosis and prediction of …

Heterogeneity of treatment effect (HTE) refers to the nonrandom variation in the magnitude
or direction of a treatment effect across levels of a covariate, as measured on a selected …

The use of evidence from clinical trials to support decisions for individual patients is a form of
“reference class forecasting”: implicit predictions for an individual are made on the basis of …

Background The introduction of non–vitamin K antagonist oral anticoagulants has been a
major advance for stroke prevention in atrial fibrillation; however, outcomes achieved in …

Abstract Objective Eating disorders (EDs) were once conceptualized as primarily affecting
affluent, White women, a misconception that informed research and practice for many years …

Male sex, early life chemical exposure and the brain aromatase enzyme have been
implicated in autism spectrum disorder (ASD). In the Barwon Infant Study birth cohort (n …

Progesterone is essential for the maintenance of pregnancy. Several small trials have
suggested that progesterone supplementation may reduce the risk of miscarriage in women …

Randomised clinical trials (RCTs) are the gold standard for providing unbiased evidence of
intervention effects. Here, we provide an overview of the history of RCTs and discuss the …