Cell types are the basic functional units of an organism. Cell types exhibit diverse
phenotypic properties at multiple levels, making them challenging to define, categorize, and …

The function of many biological systems, such as embryos, liver lobules, intestinal villi, and
tumors, depends on the spatial organization of their cells. In the past decade, high …

Brains contain networks of interconnected neurons and so knowing the network architecture
is essential for understanding brain function. We therefore mapped the synaptic-resolution …

For more than 100 years, the fruit fly Drosophila melanogaster has been one of the most
studied model organisms. Here, we present a single-cell atlas of the adult fly, Tabula …

The neural circuits responsible for animal behavior remain largely unknown. We summarize
new methods and present the circuitry of a large fraction of the brain of the fruit fly …

Flexible behaviors over long timescales are thought to engage recurrent neural networks in
deep brain regions, which are experimentally challenging to study. In insects, recurrent …

Making inferences about the computations performed by neuronal circuits from synapse-
level connectivity maps is an emerging opportunity in neuroscience. The mushroom body …

Calcium imaging with genetically encoded calcium indicators (GECIs) is routinely used to
measure neural activity in intact nervous systems. GECIs are frequently used in one of two …

SNT is an end-to-end framework for neuronal morphometry and whole-brain connectomics
that supports tracing, proof-editing, visualization, quantification and modeling of …

The view that sleep is essential for survival is supported by the ubiquity of this behavior, the
apparent existence of sleep-like states in the earliest animals, and the fact that severe sleep …