Therapeutic drug monitoring (TDM) and model‐informed precision dosing (MIPD) have
evolved as important tools to inform rational dosing of antibiotics in individual patients with …

Purpose This review provides an overview of the current challenges in oral targeted
antineoplastic drug (OAD) dosing and outlines the unexploited value of therapeutic drug …

Abstract Model-informed precision dosing (MIPD) stands as a significant development in
personalized medicine to tailor drug dosing to individual patient characteristics. MIPD moves …

Tuberculosis (TB) is still the number one cause of death due to an infectious disease.
Pharmacokinetics and pharmacodynamics of anti-TB drugs are key in the optimization of TB …

Pharmacometric methods have hugely benefited from progress in analytical and computer
sciences during the past decades, and play nowadays a central role in the clinical …

Many important drugs exhibit substantial variability in pharmacokinetics and
pharmacodynamics leading to a loss of the desired clinical outcomes or significant adverse …

The administered dose of a drug modulates whether patients will experience optimal
effectiveness, toxicity including death, or no effect at all. Dosing is particularly important for …

Polymyxin B is used as a last therapeutic option for the treatment of multidrug-resistant Gram-
negative bacterial infections. This study aimed to develop a population pharmacokinetic …

Background: Mobile health (mHealth) is a rapidly emerging market, which has been
implemented in a variety of different disease areas. Tuberculosis remains one of the most …

Treatment response variability across patients is a common phenomenon in clinical practice.
For many drugs this inter-individual variability does not require much (if any) …