Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …

Astrocytes constitute approximately 30% of the cells in the mammalian central nervous
system (CNS). They are integral to brain and spinal-cord physiology and perform many …

The diversity of cell types and regulatory states in the brain, and how these change during
aging, remains largely unknown. We present a single-cell transcriptome atlas of the entire …

Maturation of neuronal circuits requires selective elimination of synaptic connections.
Although neuron-intrinsic mechanisms are important in this process, it is increasingly …

To understand the brain, molecular details need to be overlaid onto neural wiring diagrams
so that synaptic mode, neuromodulation and critical signaling operations can be considered …

Neuronal networks are capable of undergoing rapid structural and functional changes called
plasticity, which are essential for sha** circuit function during nervous system …

Glia play crucial roles in the development and homeostasis of the nervous system. While the
GLIA in the Drosophila embryo have been well characterized, their study in the adult …

The human brain contains more than 100 trillion (1014) synaptic connections, which form all
of its neural circuits. Neuroscientists have long been interested in how this complex synaptic …

Phagocytosis, a critical early event in the microbicidal response of neutrophils, is now
appreciated to serve multiple functions in a variety of cell types. Professional phagocytes …

The definition of neuronal type and how it relates to the transcriptome are open questions.
Drosophila olfactory projection neurons (PNs) are among the best-characterized neuronal …