Mechanisms of resistance and current treatment options for glioblastoma multiforme (GBM)
Simple Summary Glioblastoma multiforme is one of the hardest-to-treat brain tumors, often
resistant to conventional treatments such as chemotherapy and radiation therapy. Despite …
resistant to conventional treatments such as chemotherapy and radiation therapy. Despite …
Pathological and molecular features of glioblastoma and its peritumoral tissue
Glioblastoma (GBM) is one of the most aggressive and lethal human brain tumors. At
present, GBMs are divided in primary and secondary on the basis of the mutational status of …
present, GBMs are divided in primary and secondary on the basis of the mutational status of …
m6A RNA methylation regulates the self-renewal and tumorigenesis of glioblastoma stem cells
RNA modifications play critical roles in important biological processes. However, the
functions of N 6-methyladenosine (m 6 A) mRNA modification in cancer biology and cancer …
functions of N 6-methyladenosine (m 6 A) mRNA modification in cancer biology and cancer …
Roles of RNA methylation by means of N6-methyladenosine (m6A) in human cancers
S Wang, C Sun, J Li, E Zhang, Z Ma, W Xu, H Li, M Qiu… - Cancer letters, 2017 - Elsevier
Reversible methylation by means of N6-methyladenosine (m 6 A) is the most prevalent
internal modification in mammalian mRNA. This RNA chemical mark is created by proteins …
internal modification in mammalian mRNA. This RNA chemical mark is created by proteins …
Novel insights on m6A RNA methylation in tumorigenesis: a double-edged sword
S Wang, P Chai, R Jia, R Jia - Molecular cancer, 2018 - Springer
Abstract N6-methyladenosine (m 6 A), the most prevalent modification of mammalian RNA,
has received increasing attention. Although m 6 A has been shown to be associated with …
has received increasing attention. Although m 6 A has been shown to be associated with …
Targeting glioblastoma stem cells: a review on biomarkers, signal pathways and targeted therapy
X Tang, C Zuo, P Fang, G Liu, Y Qiu, Y Huang… - Frontiers in …, 2021 - frontiersin.org
Glioblastoma (GBM) remains the most lethal and common primary brain tumor, even after
treatment with multiple therapies, such as surgical resection, chemotherapy, and radiation …
treatment with multiple therapies, such as surgical resection, chemotherapy, and radiation …
Obstacles to glioblastoma treatment two decades after temozolomide
Simple Summary Glioblastomas are the most common and aggressive brain tumors in
adults, with a median survival of 15 months. Treatment is surgical removal, followed by …
adults, with a median survival of 15 months. Treatment is surgical removal, followed by …
A three-dimensional (3D) organotypic microfluidic model for glioma stem cells–Vascular interactions
Glioblastoma (GBM) is one of the deadliest forms of cancer. Despite many treatment options,
prognosis of GBM remains dismal with a 5-year survival rate of 4.7%. Even then, tumors …
prognosis of GBM remains dismal with a 5-year survival rate of 4.7%. Even then, tumors …
Glioblastoma microenvironment and cellular interactions
Simple Summary This paper summarizes the crosstalk between tumor/non-tumor cells and
other elements of the glioblastoma (GB) microenvironment. In tumor pathology, glial cells …
other elements of the glioblastoma (GB) microenvironment. In tumor pathology, glial cells …
Glioma stem cells: signaling, microenvironment, and therapy
Glioblastoma remains the most common and devastating primary brain tumor despite
maximal therapy with surgery, chemotherapy, and radiation. The glioma stem cell (GSC) …
maximal therapy with surgery, chemotherapy, and radiation. The glioma stem cell (GSC) …