Alginate as a promising biopolymer in drug delivery and wound healing: A review of the state-of-the-art

MAS Abourehab, RR Rajendran, A Singh… - International Journal of …, 2022 - mdpi.com
Biopolymeric nanoparticulate systems hold favorable carrier properties for active delivery.
The enhancement in the research interest in alginate formulations in biomedical and …

Cell-Instructive Biomaterials with Native-Like Biochemical Complexity

T Marjan, N Lafuente-Gómez, A Rampal… - Annual Review of …, 2025 - annualreviews.org
Biochemical signals in native tissue microenvironments instruct cell behavior during many
biological processes ranging from developmental morphogenesis and tissue regeneration …

Integrin and syndecan binding peptide-conjugated alginate hydrogel for modulation of nucleus pulposus cell phenotype

X Tan, E Jain, MN Barcellona, E Morris, S Neal… - Biomaterials, 2021 - Elsevier
Biomaterial based strategies have been widely explored to preserve and restore the juvenile
phenotype of cells of the nucleus pulposus (NP) in degenerated intervertebral discs (IVD) …

A peptide-engineered alginate aerogel with synergistic blood-absorbing and platelet-binding capabilities to rapidly stop bleeding

C Liu, C Liu, Z Shi, D Yu, X Wang, S Liu, X Wang… - Carbohydrate …, 2023 - Elsevier
Polysaccharide matrix infused with hemostasis-stimulating chemistry represents a critical
medical need of bleeding management. Herein, we describe the development of a …

Versatile click alginate hydrogels with protease-sensitive domains as cell responsive/instructive 3D microenvironments

MI Neves, MV Magalhães, SJ Bidarra, L Moroni… - Carbohydrate …, 2023 - Elsevier
Alginate (ALG) is a widely used biomaterial to create artificial extracellular matrices (ECM)
for tissue engineering. Since it does not degrade in the human body, imparting proteolytic …

A porcine islet-encapsulation device that enables long-term discordant xenotransplantation in immunocompetent diabetic mice

K Ajima, N Tsuda, T Takaki, S Furusako… - Cell Reports …, 2023 - cell.com
Islet transplantation is an effective treatment for type 1 diabetes (T1D). However, a shortage
of donors and the need for immunosuppressants are major issues. The ideal solution is to …

The effect of molecular weight and chemical structure of cross-linkers on the properties of redox-responsive hyaluronic acid hydrogels

TT Vu, M Gulfam, SH Jo, A Rizwan, SB Joo… - International Journal of …, 2023 - Elsevier
In this work, we investigated the effect of the size and the chemical structure of crosslinkers
on the properties of hyaluronic acid-based hydrogels prepared via an inverse electron …

Tunable viscoelasticity of alginate hydrogels via serial autoclaving

H Moheimani, S Stealey, S Neal… - Advanced …, 2024 - Wiley Online Library
Alginate hydrogels are widely used as biomaterials for cell culture and tissue engineering
due to their biocompatibility and tunable mechanical properties. Reducing alginate …

Thermo-responsive hydrogels encapsulating targeted core–shell nanoparticles as injectable drug delivery systems

EG Ertugral-Samgar, AM Ozmen, O Gok - Pharmaceutics, 2023 - mdpi.com
As therapeutic agents that allow for minimally invasive administration, injectable
biomaterials stand out as effective tools with tunable properties. Furthermore, hydrogels with …

[HTML][HTML] Microstructured click hydrogels for cell contact guidance in 3D

MI Neves, SJ Bidarra, MV Magalhães, AL Torres… - Materials Today Bio, 2023 - Elsevier
The topography of the extracellular matrix (ECM) is a major biophysical regulator of cell
behavior. While this has inspired the design of cell-instructive biomaterials, the ability to …