c-Jun N-terminal kinase inhibitors as potential leads for new therapeutics for Alzheimer's diseases
SC Hepp Rehfeldt, F Majolo, MI Goettert… - International journal of …, 2020 - mdpi.com
Alzheimer's Disease (AD) is becoming more prevalent as the population lives longer. For
individuals over 60 years of age, the prevalence of AD is estimated at 40.19% across the …
individuals over 60 years of age, the prevalence of AD is estimated at 40.19% across the …
A patent review of MAPK inhibitors (2018–present)
VR Wydra, RB Ditzinger, NJ Seidler… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction The mitogen-activated protein kinase (MAPK) family consist of p38 MAP
kinases, c-Jun N-terminal kinases (JNKs) and extracellular signal-regulated kinases (ERKs) …
kinases, c-Jun N-terminal kinases (JNKs) and extracellular signal-regulated kinases (ERKs) …
Fluoxetine regulates eEF2 activity (phosphorylation) via HDAC1 inhibitory mechanism in an LPS-induced mouse model of depression
Background Selective serotonin reuptaker inhibitors, including fluoxetine, are widely studied
and prescribed antidepressants, while their exact molecular and cellular mechanism are yet …
and prescribed antidepressants, while their exact molecular and cellular mechanism are yet …
A selective p38α/β MAPK inhibitor alleviates neuropathology and cognitive impairment, and modulates microglia function in 5XFAD mouse
Background Chronic neuroinflammation, aggressive amyloid beta (Aβ) deposition, neuronal
cell loss, and cognitive impairment are pathological presentations of Alzheimer's disease …
cell loss, and cognitive impairment are pathological presentations of Alzheimer's disease …
Anti-inflammatory and anti-migratory activities of isoquinoline-1-carboxamide derivatives in LPS-treated BV2 microglial cells via inhibition of MAPKs/NF-κB pathway
HTT Do, BP Bui, S Sim, JK Jung, H Lee… - International journal of …, 2020 - mdpi.com
Eleven novel isoquinoline-1-carboxamides (HSR1101~ 1111) were synthesized and
evaluated for their effects on lipopolysaccharide (LPS)-induced production of pro …
evaluated for their effects on lipopolysaccharide (LPS)-induced production of pro …
Attenuation of p38 MAPK/NF‐κB/TRPV1/CGRP is involved in the antinociceptive effect of hesperidin methyl chalcone and taxifolin in paclitaxel‐induced peripheral …
Paclitaxel (PTX)‐induced peripheral neuropathy (PIPN) is a disabling side effect of PTX,
which adversely affects the life quality of cancer patients. Flavonoids such as hesperidin …
which adversely affects the life quality of cancer patients. Flavonoids such as hesperidin …
Prenatal hyperhomocysteinemia induces glial activation and alters neuroinflammatory marker expression in infant rat hippocampus
AD Shcherbitskaia, DS Vasilev, YP Milyutina… - Cells, 2021 - mdpi.com
Maternal hyperhomocysteinemia is one of the common complications of pregnancy that
causes offspring cognitive deficits during postnatal development. In this study, we …
causes offspring cognitive deficits during postnatal development. In this study, we …
Therapeutic targeting strategies for early-to late-staged Alzheimer's disease
Alzheimer's disease (AD) is the most common cause of dementia, typically showing
progressive neurodegeneration in aging brains. The key signatures of the AD progression …
progressive neurodegeneration in aging brains. The key signatures of the AD progression …
Corydalis saxicola Alkaloids Attenuate Cisplatin-Induced Neuropathic Pain by Reducing Loss of IENF and Blocking TRPV1 Activation
CP Kuai, LJ Ju, PP Hu, F Huang - The American Journal of Chinese …, 2020 - World Scientific
Chemotherapy-induced peripheral neuropathy (CIPN) is a common complication of
cisplatin, which is characterized by intolerable paresthesia, burning, and hyperalgesia, and …
cisplatin, which is characterized by intolerable paresthesia, burning, and hyperalgesia, and …
Supramolecular assemblies with spatio-temporal sequential drug delivery capability treat spinal cord injuryvianeuroprotection and immunoregulation
P Xu, TT Li, BC Wang, YJ Yi, WC Zhang… - … Clinics and Research, 2023 - journals.lww.com
Spinal cord injury (SCI) can result in irreversible motor and sensory deficits. However, up to
data, clinical first-line drugs have ambiguous benefits and debilitating side effects, mainly …
data, clinical first-line drugs have ambiguous benefits and debilitating side effects, mainly …