Temperature, hydrostatic pressure, and osmolyte effects on liquid–liquid phase separation in protein condensates: physical chemistry and biological implications
H Cinar, Z Fetahaj, S Cinar, RM Vernon… - … A European Journal, 2019 - Wiley Online Library
Liquid–liquid phase separation (LLPS) of proteins and other biomolecules play a critical role
in the organization of extracellular materials and membrane‐less compartmentalization of …
in the organization of extracellular materials and membrane‐less compartmentalization of …
Potential and limits of a colloid approach to protein solutions
A Stradner, P Schurtenberger - Soft Matter, 2020 - pubs.rsc.org
Looking at globular proteins with the eyes of a colloid scientist has a long tradition, in fact a
significant part of the early colloid literature was focused on protein solutions. However, it …
significant part of the early colloid literature was focused on protein solutions. However, it …
Dynamics of proteins in solution
The dynamics of proteins in solution includes a variety of processes, such as backbone and
side-chain fluctuations, interdomain motions, as well as global rotational and translational …
side-chain fluctuations, interdomain motions, as well as global rotational and translational …
Slow-down in diffusion in crowded protein solutions correlates with transient cluster formation
For a long time, the effect of a crowded cellular environment on protein dynamics has been
largely ignored. Recent experiments indicate that proteins diffuse more slowly in a living cell …
largely ignored. Recent experiments indicate that proteins diffuse more slowly in a living cell …
Salicylic acid regulates PIN2 auxin transporter hyperclustering and root gravitropic growth via Remorin‐dependent lipid nanodomain organisation in Arabidopsis …
To adapt to the diverse array of biotic and abiotic cues, plants have evolved sophisticated
mechanisms to sense changes in environmental conditions and modulate their growth …
mechanisms to sense changes in environmental conditions and modulate their growth …
Resolving molecular diffusion and aggregation of antibody proteins with megahertz X-ray free-electron laser pulses
X-ray free-electron lasers (XFELs) with megahertz repetition rate can provide novel insights
into structural dynamics of biological macromolecule solutions. However, very high dose …
into structural dynamics of biological macromolecule solutions. However, very high dose …
Probing cage relaxation in concentrated protein solutions by X-ray photon correlation spectroscopy
Diffusion of proteins on length scales of their size is crucial for understanding the machinery
of living cells. X-ray photon correlation spectroscopy (XPCS) is currently the only way to …
of living cells. X-ray photon correlation spectroscopy (XPCS) is currently the only way to …
Real space analysis of colloidal gels: Triumphs, challenges and future directions
CP Royall, MA Faers, SL Fussell… - Journal of Physics …, 2021 - iopscience.iop.org
Colloidal gels constitute an important class of materials found in many contexts and with a
wide range of applications. Yet as matter far from equilibrium, gels exhibit a variety of time …
wide range of applications. Yet as matter far from equilibrium, gels exhibit a variety of time …
Pressure-sensitive and osmolyte-modulated liquid–liquid phase separation of eye-lens γ-crystallins
S Cinar, H Cinar, HS Chan… - Journal of the American …, 2019 - ACS Publications
Biomolecular condensates can be functional (eg, as membrane-less organelles) or
dysfunctional (eg, as precursors to pathological protein aggregates). A major physical …
dysfunctional (eg, as precursors to pathological protein aggregates). A major physical …
Soft condensed matter physics of foods and macronutrients
Understanding food properties is paramount for enhancing features such as appearance,
taste and texture, for improving health-related factors such as minimizing the onset of …
taste and texture, for improving health-related factors such as minimizing the onset of …