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Aging and remodeling during healing of the wounded heart: current therapies and novel drug targets
BI Jugdutt - Current Drug Targets, 2008 - ingentaconnect.com
Aging has become a major health care problem and socio-economic burden worldwide.
Myocardial infarction (MI) is the major killer worldwide and coronary reperfusion is the major …
Myocardial infarction (MI) is the major killer worldwide and coronary reperfusion is the major …
Glucocorticoid modulates angiotensin II receptor expression patterns and protects the heart from ischemia and reperfusion injury
Glucocorticoid regulates angiotensin II receptor (ATR) expression via activating
glucocorticoid receptors and binding to glucocorticoid response elements. The regulation of …
glucocorticoid receptors and binding to glucocorticoid response elements. The regulation of …
Angiotensin II activates NADPH oxidase in isolated rat hearts subjected to ischaemia–reperfusion
A Oudot, C Vergely, A Ecarnot-Laubriet… - European journal of …, 2003 - Elsevier
The role of angiotensin II in myocardial ischaemia–reperfusion is not clearly defined. In this
respect, the involvement of NADPH oxidase remains to be determined. The aim of this study …
respect, the involvement of NADPH oxidase remains to be determined. The aim of this study …
Preconditioning of rat hearts by adenosine A1 or A3 receptor activation
R De Jonge, M Out, WJ Maas, JW De Jong - European journal of …, 2002 - Elsevier
Our study in rat hearts examined whether activation of adenosine A1 or A3 receptors
improved functional recovery and reduced apoptosis resulting from low-flow ischemia. Prior …
improved functional recovery and reduced apoptosis resulting from low-flow ischemia. Prior …
AT1 and AT2 receptor expression and blockade after acute ischemia-reperfusion in isolated working rat hearts
We assessed ANG II type 1 (AT1) and type 2 (AT2) receptor (R) expression and functional
recovery after ischemia-reperfusion with or without AT1R/AT2R blockade in isolated working …
recovery after ischemia-reperfusion with or without AT1R/AT2R blockade in isolated working …
Role of p90 ribosomal S6 kinase–mediated Prorenin-converting enzyme in ischemic and diabetic myocardium
S Itoh, B Ding, T Shishido, N Lerner-Marmarosh… - Circulation, 2006 - ahajournals.org
Background—Epidemiological data strongly indicate that diabetes increases the incidence
of heart failure. Although the benefit of angiotensin-converting enzyme inhibitor (ACE-I) …
of heart failure. Although the benefit of angiotensin-converting enzyme inhibitor (ACE-I) …
Postischemic apoptosis and functional recovery after angiotensin II type 1 receptor blockade in isolated working rat hearts
Objective To determine whether chronic angiotensin (AngII) type I receptor (AT 1 R)
blockade inhibits cardiomyocyte (CM) apoptosis and attenuates left ventricular (LV) …
blockade inhibits cardiomyocyte (CM) apoptosis and attenuates left ventricular (LV) …
Enhanced expression of angiotensin II type 2 receptor, inositol 1, 4, 5-trisphosphate receptor, and protein kinase Cε during cardioprotection induced by angiotensin II …
Y Xu, AS Clanachan, BI Jugdutt - Hypertension, 2000 - ahajournals.org
We hypothesized that the cardioprotective effect of angiotensin II type 2 receptor (AT2R)
blockade with PD 123,319 (PD) on the recovery of left ventricular (LV) mechanical function …
blockade with PD 123,319 (PD) on the recovery of left ventricular (LV) mechanical function …
Cardioprotection induced by AT1R blockade after reperfused myocardial infarction: Association with regional increase in AT2R, IP3R and PKCε proteins and cGMP
BI Jugdutt, Y Xu, M Balghith… - Journal of …, 2000 - journals.sagepub.com
Background: We hypothesized that the cardioprotective effect of angiotensin II (AngII) type 1
receptor (AT, R) blockade during in vivo ischemia-reperfusion (IR) might be associated with …
receptor (AT, R) blockade during in vivo ischemia-reperfusion (IR) might be associated with …
Angiotensin II reduces infarct size and has no effect on post‐ischaemic contractile dysfunction in isolated rat hearts
WR Ford, AS Clanachan… - British Journal of …, 2001 - Wiley Online Library
In order to test the hypothesis that angiotensin II exacerbates myocardial ischaemia‐
reperfusion (IR) injury, we examined the effects of graded angiotension II concentrations of …
reperfusion (IR) injury, we examined the effects of graded angiotension II concentrations of …