[HTML][HTML] Dysfunctional and dysregulated nitric oxide synthases in cardiovascular disease: mechanisms and therapeutic potential

R Roy, J Wilcox, AJ Webb, K O'Gallagher - International journal of …, 2023 - mdpi.com
Nitric oxide (NO) plays an important and diverse signalling role in the cardiovascular system,
contributing to the regulation of vascular tone, endothelial function, myocardial function …

[HTML][HTML] Arginine and endothelial function

J Gambardella, W Khondkar, MB Morelli, X Wang… - Biomedicines, 2020 - mdpi.com
Arginine (L-arginine), is an amino acid involved in a number of biological processes,
including the biosynthesis of proteins, host immune response, urea cycle, and nitric oxide …

Endothelial dysfunction due to eNOS uncoupling: molecular mechanisms as potential therapeutic targets

A Janaszak-Jasiecka, A Płoska, JM Wierońska… - Cellular & molecular …, 2023 - Springer
Nitric oxide (NO) is one of the most important molecules released by endothelial cells, and
its antiatherogenic properties support cardiovascular homeostasis. Diminished NO …

The vicious cycle of type 2 diabetes mellitus and skeletal muscle atrophy: clinical, biochemical, and nutritional bases

JM Lopez-Pedrosa, M Camprubi-Robles… - Nutrients, 2024 - mdpi.com
Today, type 2 diabetes mellitus (T2DM) and skeletal muscle atrophy (SMA) have become
increasingly common occurrences. Whether the onset of T2DM increases the risk of SMA or …

[HTML][HTML] Obesity and endothelial function

M Kajikawa, Y Higashi - Biomedicines, 2022 - mdpi.com
Obesity is a major public health problem and is related to increasing rates of cardiovascular
morbidity and mortality. Over 1.9 billion adults are overweight or obese worldwide and the …

Effects of arginine supplementation on athletic performance based on energy metabolism: A systematic review and meta-analysis

A Viribay, J Burgos, J Fernández-Landa, J Seco-Calvo… - Nutrients, 2020 - mdpi.com
Nitric oxide related ergogenic aids such as arginine (Arg) have shown to impact positively
on sport performance through several physiological and metabolic mechanisms. However …

Role of the eNOS uncoupling and the nitric oxide metabolic pathway in the pathogenesis of autoimmune rheumatic diseases

A Łuczak, M Madej, A Kasprzyk… - Oxidative Medicine and …, 2020 - Wiley Online Library
Atherosclerosis and its clinical complications constitute the major healthcare problems of the
world population. Due to the central role of endothelium throughout the atherosclerotic …

[HTML][HTML] Type 1 and type 2 diabetes mellitus: Commonalities, differences and the importance of exercise and nutrition

M Krause, G De Vito - Nutrients, 2023 - mdpi.com
Diabetes mellitus represents a group of physiological dysfunctions characterized by
hyperglycaemia resulting directly from insulin resistance (in the case of type 2 diabetes …

[HTML][HTML] Exploring the medicinal significance of l-Arginine mediated nitric oxide in preventing health disorders

MO Oyovwi, AD Atere - European Journal of Medicinal Chemistry Reports, 2024 - Elsevier
Abstract l-Arginine is an essential amino acid that plays a crucial role in various
physiological processes. It serves as a precursor for nitric oxide (NO), which has potent …

Diet in the management of type 2 diabetes: umbrella review of systematic reviews with meta-analyses of randomised controlled trials

E Szczerba, J Barbaresko, T Schiemann… - BMJ …, 2023 - pmc.ncbi.nlm.nih.gov
Objective To systematically summarise and evaluate the existing evidence on the effect of
diet on the management of type 2 diabetes and prevention of complications. Design …