Sirtuin activators and inhibitors: Promises, achievements, and challenges
H Dai, DA Sinclair, JL Ellis, C Steegborn - Pharmacology & therapeutics, 2018 - Elsevier
The NAD+-dependent protein lysine deacylases of the Sirtuin family regulate various
physiological functions, from energy metabolism to stress responses. The human Sirtuin …
physiological functions, from energy metabolism to stress responses. The human Sirtuin …
Recent advance in oxazole-based medicinal chemistry
HZ Zhang, ZL Zhao, CH Zhou - European journal of medicinal chemistry, 2018 - Elsevier
Oxazole compounds containing nitrogen and oxygen atoms in the five-membered aromatic
ring are readily able to bind with a variety of enzymes and receptors in biological systems …
ring are readily able to bind with a variety of enzymes and receptors in biological systems …
SIRT2: Controversy and multiple roles in disease and physiology
Y Wang, J Yang, T Hong, X Chen, L Cui - Ageing research reviews, 2019 - Elsevier
Abstract Sirtuin 2 (SIRT2) is an NAD+-dependent deacetylase that was under studied
compared to other sirtuin family members. SIRT2 is the only sirtuin protein which is …
compared to other sirtuin family members. SIRT2 is the only sirtuin protein which is …
Biological activity of oxadiazole and thiadiazole derivatives
UA Atmaram, SM Roopan - Applied Microbiology and Biotechnology, 2022 - Springer
The 5-membered oxadiazole and thiadiazole scaffolds are the most privileged and well-
known heterocycles, being a common and essential feature of a variety of natural products …
known heterocycles, being a common and essential feature of a variety of natural products …
An overview of Sirtuins as potential therapeutic target: Structure, function and modulators
Y Wang, J He, M Liao, M Hu, W Li, H Ouyang… - European journal of …, 2019 - Elsevier
Abstract Sirtuin (Yeast Silent Information RegulatorsⅡ, Sir2) was first discovered in the
1970s. Because of its function by removing acetylated groups from histones in the presence …
1970s. Because of its function by removing acetylated groups from histones in the presence …
Novel 1, 2, 4-oxadiazole derivatives in drug discovery
Five-membered 1, 2, 4-oxadiazole heterocyclic ring has received considerable attention
because of its unique bioisosteric properties and an unusually wide spectrum of biological …
because of its unique bioisosteric properties and an unusually wide spectrum of biological …
Novel 1, 4-dihydropyridines as specific binders and activators of SIRT3 impair cell viability and clonogenicity and downregulate hypoxia-induced targets in cancer …
The mitochondrial SIRT3 modulates several biological pathways such as cancer,
metabolism, and hypoxia-related diseases. Recently, we discovered new 1, 4 …
metabolism, and hypoxia-related diseases. Recently, we discovered new 1, 4 …
Potent and specific activators for mitochondrial sirtuins Sirt3 and Sirt5
Sirtuins are NAD+-dependent protein deacylases involved in metabolic regulation and
aging-related diseases. Specific activators for seven human Sirtuin isoforms would be …
aging-related diseases. Specific activators for seven human Sirtuin isoforms would be …
[HTML][HTML] A review on synthetic account of 1, 2, 4-oxadiazoles as anti-infective agents
TM Dhameliya, SJ Chudasma, TM Patel, BP Dave - Molecular Diversity, 2022 - Springer
Most of the currently marketed drugs consist of heterocyclic scaffolds containing nitrogen
and or oxygen as heteroatoms in their structures. Several research groups have synthesized …
and or oxygen as heteroatoms in their structures. Several research groups have synthesized …
The roles of sirtuin family proteins in cancer progression
E Zhao, J Hou, X Ke, MN Abbas, S Kausar, L Zhang… - Cancers, 2019 - mdpi.com
Sirtuin family members are characterized by either mono-ADP-ribosyltransferase or
deacylase activity and are linked to various cancer-related biological pathways as regulators …
deacylase activity and are linked to various cancer-related biological pathways as regulators …