Highlights•NLRP1 is a sensor of diverse pathogen-encoded activities.•'Functional
degradation'provides a mechanism for NLRP1 activation.•New insights into NLRP1 have …

Neurons are highly specialized cells of the nervous system that receive, process and
transmit electrical signals critical for normal brain function. Here, we review the intricate …

Nucleotide-binding domain and leucine-rich repeat pyrin-domain containing protein 1
(NLRP1) is an inflammasome sensor that mediates the activation of caspase-1 to induce …

Spectrin and ankyrin are membrane skeletal proteins that contribute to mechanical support
of plasma membranes and micron-scale organization of diverse membrane-spanning …

Ankyrins are membrane-associated proteins that together with their spectrin partners are
responsible for micron-scale organization of vertebrate plasma membranes, including those …

The axon initial segment is a highly specialized neuronal compartment, identified almost 50
years ago by the pioneers of electron microscopy. Located in the first 50 μm of the axon, it …

Axon growth requires long-range transport of organelles, but how these cargoes recruit their
motors and how their traffic is regulated are not fully resolved. In this paper, we identify a …

Since an intact membrane is required for normal cellular homeostasis, membrane repair is
essential for cell survival. Human genetic studies, combined with the development of novel …

The death fold domain-containing protein PIDD1 has recently attracted renewed attention as
a regulator of the orphan cell death-related protease, Caspase-2. Caspase-2 can activate …

Ankyrin adaptors together with their spectrin partners coordinate diverse ion channels and
cell adhesion molecules within plasma membrane domains and thereby promote …