[HTML][HTML] Combination therapy in combating cancer

RB Mokhtari, TS Homayouni, N Baluch… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Combination therapy, a treatment modality that combines two or more therapeutic agents, is
a cornerstone of cancer therapy. The amalgamation of anti-cancer drugs enhances efficacy …

Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals

YJ Surh, JK Kundu, HK Na - Planta medica, 2008 - thieme-connect.com
A wide array of dietary phytochemicals have been reported to induce the expression of
enzymes involved in both cellular antioxidant defenses and elimination/inactivation of …

Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1

A Kobayashi, MI Kang, Y Watai, KI Tong… - … and cellular biology, 2006 - Taylor & Francis
The Keap1-Nrf2 system is the major regulatory pathway of cytoprotective gene expression
against oxidative and/or electrophilic stresses. Keap1 acts as a stress sensor protein in this …

Oxidative stress in ALS: key role in motor neuron injury and therapeutic target

SC Barber, PJ Shaw - Free Radical Biology and Medicine, 2010 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder
characterized by death of motor neurons leading to muscle wasting, paralysis, and death …

Citrus flavonoids and their antioxidant evaluation

Y Wang, XJ Liu, JB Chen, JP Cao, X Li… - Critical Reviews in …, 2022 - Taylor & Francis
The antioxidant ability is the link and bridge connecting a variety of biological activities.
Citrus flavonoids play an essential role in regulating oxidative stress and are an important …

Sulforaphane: its “coming of age” as a clinically relevant nutraceutical in the prevention and treatment of chronic disease

CA Houghton - Oxidative medicine and cellular longevity, 2019 - Wiley Online Library
A growing awareness of the mechanisms by which phytochemicals can influence upstream
endogenous cellular defence processes has led to intensified research into their potential …

Bioactive S-alk (en) yl cysteine sulfoxide metabolites in the genus Allium: the chemistry of potential therapeutic agents

P Rose, M Whiteman, PK Moore, YZ Zhu - Natural product reports, 2005 - pubs.rsc.org
Covering: 1892 to 2004 S-Alk (en) yl cysteine sulfoxides are odourless, non-protein sulfur
amino acids typically found in members of the family Alliaceae and are the precursors to the …

[HTML][HTML] Resveratrol protects diabetic kidney by attenuating hyperglycemia-mediated oxidative stress and renal inflammatory cytokines via Nrf2–Keap1 signaling

P Palsamy, S Subramanian - … et Biophysica Acta (BBA)-Molecular Basis of …, 2011 - Elsevier
Hyperglycemia-mediated oxidative stress plays a crucial role in the progression of diabetic
nephropathy. Hence, the present study was hypothesized to explore the renoprotective …

[HTML][HTML] Oxidative stress in ALS: a mechanism of neurodegeneration and a therapeutic target

SC Barber, RJ Mead, PJ Shaw - … et Biophysica Acta (BBA)-Molecular Basis …, 2006 - Elsevier
The cause (s) of amyotrophic lateral sclerosis (ALS) is not fully understood in the vast
majority of cases and the mechanisms involved in motor neuron degeneration are multi …

Role of Nrf2 signaling cascade in breast cancer: strategies and treatment

H Kumar, RM Kumar, D Bhattacharjee… - Frontiers in …, 2022 - frontiersin.org
Breast cancer is the second leading cancer among all types of cancers. It accounts for 12%
of the total cases of cancers. The complex and heterogeneous nature of breast cancer …