Despite the success of renin-angiotensin system (RAS) blockade by angiotensin-converting
enzyme (ACE) inhibitors and angiotensin II type 1 receptor (AT 1 R) blockers, current …

Zn2+ ions are essential in many physiological processes, including enzyme catalysis,
protein structural stabilization, and the regulation of many proteins. The affinities of proteins …

Genetic mechanisms of blood pressure (BP) regulation remain poorly defined. Using kidney-
specific epigenomic annotations and 3D genome information we generated and validated …

M1 aminopeptidase enzymes are a diverse family of metalloenzymes characterized by
conserved structure and reaction specificity. Excluding viruses, M1 aminopeptidases are …

M1 aminopeptidase is a metallopeptidase that plays a vital role in protein catabolism and
has been identified as a validated drug target in various parasites; however, our …

Hypertension affects one-third of the adult population and is a growing problem due to the
increasing incidence of obesity and diabetes. Brain RAS (renin–angiotensin system) …

Research on SARS-CoV-2, the viral pathogen that causes COVID-19, has identified
angiotensin converting enzyme 2 (ACE2) as the primary viral receptor. Several genes that …

Insulin‐regulated aminopeptidase (IRAP or oxytocinase) is a membrane‐bound zinc‐
metallopeptidase that cleaves neuroactive peptides in the brain and produces memory …

Mosquito-based malaria transmission–blocking vaccines (mTBVs) target midgut-surface
antigens of the Plasmodium parasite's obligate vector, the Anopheles mosquito. The alanyl …

Tumor cell surface aminopeptidase N (APN or CD13) has two puzzling functions unrelated
to its enzymatic activity: mediating tumor cell motility and serving as a receptor for tumor …