Wilson disease (WD) is a potentially treatable, inherited disorder of copper metabolism that
is characterized by the pathological accumulation of copper. WD is caused by mutations in …

Background The dietary consumption of cuprizone–a copper chelator–has long been known
to induce demyelination of specific brain structures and is widely used as model of multiple …

The cuprizone mouse model allows the investigation of the complex molecular mechanisms
behind nonautoimmune-mediated demyelination and spontaneous remyelination. While it is …

Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating disease that affects the
central nervous system and represents the most common neurological disorder in young …

Polar lipids are amphiphilic lipids with a hydrophilic head and a hydrophobic tail. Polar lipids
mainly include phospholipids and sphingolipids. They are structural components of neural …

Human milk contains sphingomyelin (SM) as a major component of the phospholipid
fraction. Galactosylceramide (cerebroside), a metabolite of sphingolipids, increases along …

To understand the mechanisms of remyelination and the reasons for regeneration failure is
one of the major challenges in multiple sclerosis research. This requires a good knowledge …

Background: Recent data suggest that statins may be potent immunomodulatory agents. In
order to evaluate the potential role of statins as immunomodulators in MS, the authors …

In the present work we analyzed the capacity of thyroid hormones (THs) to improve
remyelination using a rat model of cuprizone-induced demyelination previously described in …

Sonic hedgehog (Shh) signaling influences neurogenesis and neural patterning during the
development of central nervous system. Dysregulation of Shh signaling in brain leads to …