Prognostic biomarkers are of great significance to predict the outcome of patients with
cancer, to guide the clinical treatments, to elucidate tumorigenesis mechanisms, and offer …

An integrative multi-omics database is needed urgently, because focusing only on analysis
of one-dimensional data falls far short of providing an understanding of cancer. Previously …

Abstract Background Data mining of The Cancer Genome Atlas (TCGA) data has
significantly facilitated cancer genome research and provided unprecedented opportunities …

Cancer immune evasion is one of the hallmarks of carcinogenesis. Cancer cells employ
multiple mechanisms to avoid immune recognition and suppress antitumor immune …

Mismatch repair–deficient (MMRd) cancers have varied responses to immune-checkpoint
blockade (ICB). We conducted a phase II clinical trial of the PD-1 inhibitor pembrolizumab in …

Background The RUNX family of transcription factors plays an important regulatory role in
tumor development. Although the importance of RUNX in certain cancer types is well known …

Background Emerging evidence suggests that secreted phosphoprotein 1 (SPP1) is
involved in tumor cell progression in multiple cancer types. However, the role of SPP1 in …

Inhibin subunit beta A (INHBA) is a member of the transforming growth factor-beta (TGF-β)
superfamily that plays a fundamental role in various cancers. However, a systematic …

Long non-coding RNAs (lncRNAs) play a significant role in multiple human cancers as
competing endogenous RNAs (ceRNAs). However, a systematic mRNA-microRNA (miRNA) …

Background CD276 (also known as B7-H3) is one of the most important immune
checkpoints of the CD28 and B7 superfamily, and its abnormal expression is closely …