The dawn of a new era: targeting the “undruggables” with antibody-based therapeutics
The high selectivity and affinity of antibodies toward their antigens have made them a highly
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …
A “crossbreeding” dyad strategy for bright and small-molecular weight near-infrared fluorogens: From the structural design to boost aggregation-induced emission
J Li, M Zhao, J Huang, P Liu, X Luo, Y Zhang… - Coordination Chemistry …, 2022 - Elsevier
The development of high-performance near-infrared fluorophores has gained tremendous
attention for spatiotemporally in vivo dynamical bioimaging. The proposed π-conjugated …
attention for spatiotemporally in vivo dynamical bioimaging. The proposed π-conjugated …
A general strategy to develop fluorogenic polymethine dyes for bioimaging
A Martin, P Rivera-Fuentes - Nature Chemistry, 2024 - nature.com
Fluorescence imaging is an invaluable tool to study biological processes and further
progress depends on the development of advanced fluorogenic probes that reach …
progress depends on the development of advanced fluorogenic probes that reach …
Subcellular targeting strategies for protein and peptide delivery
H Su, G Rong, L Li, Y Cheng - Advanced Drug Delivery Reviews, 2024 - Elsevier
Cytosolic delivery of proteins and peptides provides opportunities for effective disease
treatment, as they can specifically modulate intracellular processes. However, most of …
treatment, as they can specifically modulate intracellular processes. However, most of …
A Hoechst Reporter Enables Visualization of Drug Engagement In Vitro and In Vivo: Toward Safe and Effective Nanodrug Delivery
T Miyazaki, S Chen, S Florinas, K Igarashi… - Acs Nano, 2022 - ACS Publications
Assessment of drug activation and subsequent interaction with targets in living tissues could
guide nanomedicine design, but technologies enabling insight into how a drug reaches and …
guide nanomedicine design, but technologies enabling insight into how a drug reaches and …
Structure–activity relationships of antibody-drug conjugates: a systematic review of chemistry on the Trastuzumab scaffold
Antibody-drug conjugates (ADCs) are a rapidly growing class of cancer therapeutics that
seek to overcome the low therapeutic index of conventional cytotoxic agents. However …
seek to overcome the low therapeutic index of conventional cytotoxic agents. However …
Concurrent Subcellular Delivery of Hydrogen Sulfide and a Payload with Near-Infrared Light
K Hanc, H Janeková, P Štacko - JACS Au, 2024 - ACS Publications
Hydrogen sulfide (H2S) is a gaseous signaling molecule, exerting crucial regulatory
functions in organelles and cellular environments. H2S exhibits high therapeutic potential …
functions in organelles and cellular environments. H2S exhibits high therapeutic potential …
Rejuvenating old fluorophores with new chemistry
The field of organic chemistry began with 19th century scientists identifying and then
expanding upon synthetic dye molecules for textiles. In the 20th century, dye chemistry …
expanding upon synthetic dye molecules for textiles. In the 20th century, dye chemistry …
Synthesis and biological evaluation of theranostic Trastuzumab–SN38 conjugate for Near-IR fluorescence imaging and targeted therapy of HER2+ breast cancer
Here, we report on the design, synthesis, and biological evaluation of a new theranostic
antibody drug conjugate (ADC), Cy5-Ab-SS-SN38, that consists of the HER2-specific …
antibody drug conjugate (ADC), Cy5-Ab-SS-SN38, that consists of the HER2-specific …
Modified norcyanines enable ratiometric pH imaging beyond 1000 nm
Activatable fluorophores with emission beyond 1000 nm have the potential to enable high
contrast imaging in complex in vivo settings. However, there are few scaffolds that can be …
contrast imaging in complex in vivo settings. However, there are few scaffolds that can be …