Mitochondrial machineries for protein import and assembly

N Wiedemann, N Pfanner - Annual review of biochemistry, 2017 - annualreviews.org
Mitochondria are essential organelles with numerous functions in cellular metabolism and
homeostasis. Most of the> 1,000 different mitochondrial proteins are synthesized as …

Importing mitochondrial proteins: machineries and mechanisms

A Chacinska, CM Koehler, D Milenkovic, T Lithgow… - Cell, 2009 - cell.com
Most mitochondrial proteins are synthesized on cytosolic ribosomes and must be imported
across one or both mitochondrial membranes. There is an amazingly versatile set of …

Role of the TOM complex in protein import into mitochondria: structural views

Y Araiso, K Imai, T Endo - Annual Review of Biochemistry, 2022 - annualreviews.org
Mitochondria are central to energy production, metabolism and signaling, and apoptosis. To
make new mitochondria from preexisting mitochondria, the cell needs to import …

Structure of the mitochondrial import gate reveals distinct preprotein paths

Y Araiso, A Tsutsumi, J Qiu, K Imai, T Shiota, J Song… - Nature, 2019 - nature.com
The translocase of the outer mitochondrial membrane (TOM) is the main entry gate for
proteins,,–. Here we use cryo-electron microscopy to report the structure of the yeast TOM …

Genomic structure in Europeans dating back at least 36,200 years

A Seguin-Orlando, TS Korneliussen, M Sikora… - Science, 2014 - science.org
The origin of contemporary Europeans remains contentious. We obtained a genome
sequence from Kostenki 14 in European Russia dating from 38,700 to 36,200 years ago …

[BOOK][B] The structure of biological membranes

PL Yeagle - 2004 - taylorfrancis.com
Recent research has provided an abundance of new information on membrane
biochemistry. Now more than ever, it is essential to update our current understanding of …

Machinery for protein sorting and assembly in the mitochondrial outer membrane

N Wiedemann, V Kozjak, A Chacinska, B Schönfisch… - Nature, 2003 - nature.com
Mitochondria contain translocases for the transport of precursor proteins across their outer
and inner membranes,,,,. It has been assumed that the translocases also mediate the sorting …

[HTML][HTML] Mitochondrial protein import: common principles and physiological networks

J Dudek, P Rehling, M van der Laan - Biochimica et Biophysica Acta (BBA) …, 2013 - Elsevier
Most mitochondrial proteins are encoded in the nucleus. They are synthesized as precursor
forms in the cytosol and must be imported into mitochondria with the help of different protein …

Molecular architecture of the active mitochondrial protein gate

T Shiota, K Imai, J Qiu, VL Hewitt, K Tan, HH Shen… - Science, 2015 - science.org
Mitochondria fulfill central functions in cellular energetics, metabolism, and signaling. The
outer membrane translocator complex (the TOM complex) imports most mitochondrial …

Evolutionary conservation of biogenesis of β-barrel membrane proteins

SA Paschen, T Waizenegger, T Stan, M Preuss… - Nature, 2003 - nature.com
The outer membranes of mitochondria and chloroplasts are distinguished by the presence of
β-barrel membrane proteins,. The outer membrane of Gram-negative bacteria also harbours …