Numerous physiological and pathological stimuli promote the rearrangement of the actin
cytoskeleton, thereby modulating cellular motile functions. Although it seems intuitively …

Serum response factor (SRF) is a widely expressed transcription factor involved in
orchestrating disparate programs of gene expression linked to muscle differentiation and …

The vast diversity of cellular types and behaviours is mainly the result of combinatorial
interactions between a limited number of transcription factors and cellular signalling …

During the processes leading to adverse cardiac remodeling and heart failure,
cardiomyocytes react to neurohumoral stimuli and biomechanical stress by activating …

The heart develops from two bilateral heart fields that are formed during early gastrulation. In
recent years, signaling pathways that specify cardiac mesoderm have been extensively …

During the past decade, emerging evidence has accumulated of different nuclear
transcription factors in regulation of cardiac development and growth as well as in cardiac …

Congenital heart disease is a major cause of morbidity and mortality throughout life.
Mutations in numerous transcription factors have been identified in patients and families with …

Objectives: The purpose of this study was to estimate the frequency of NKX2. 5 mutations in
specific cardiovascular anomalies and investigate genotype-phenotype correlations in …

Cardiac hypertrophy is one of the main ways in which cardiomyocytes respond to
mechanical and neurohormonal stimuli. It enables myocytes to increase their work output …

MicroRNAs (miRNAs) are endogenous, small ribonucleotides regulating the translation of
target messenger RNAs that have been shown to be involved in orchestrating growth …