Background Recently, the hallmarks of aging were updated to include dysbiosis, disabled
macroautophagy, and chronic inflammation. In particular, the low-grade chronic …

Aging accompanied by several age-related complications, is a multifaceted inevitable
biological progression involving various genetic, environmental, and lifestyle factors. The …

Aging involves seemingly paradoxical changes in energy metabolism. Molecular damage
accumulation increases cellular energy expenditure, yet whole-body energy expenditure …

Cellular metabolism is a flexible and plastic network that often dictates physiological and
pathological states of the cell, including differentiation, cancer, and aging. Recent advances …

Background During aging, the human methylome undergoes both differential and variable
shifts, accompanied by increased entropy. The distinction between variably methylated …

The problem of the degradation and aging of bioorganisms is herein considered from the
viewpoint of statistical physics. Two typical timescales in biological systems—the time of …

Drug repurposing refers to excavating clinically approved drugs for new clinical indications,
effectively shortening the cost and time of clinical evaluation due to the established …

Introduction University students are a special population group characterized by changes in
BMI values over the subsequent years of education, with an upward tendency to BMI. The …

Diabetic kidney disease is a major microvascular diabetes mellitus (DM) complication
clinically associated with a gradual renal function decline. Although metformin is a common …

Age-associated osteoporosis (AAOP) poses a significant health burden, characterized by
increased fracture risk due to declining bone mass and strength. Effective prevention and …