Although we have come a long way in our understanding of the signals that drive cancer
growth, and how these signals can be targeted, effective control of this disease remains a …

Medulloblastoma (MB) comprises a biologically heterogeneous group of embryonal tumours
of the cerebellum. Four subgroups of MB have been described (WNT, sonic hedgehog …

Medulloblastoma, a malignant childhood cerebellar tumour, segregates molecularly into
biologically distinct subgroups, suggesting that a personalized approach to therapy would …

Current therapies for medulloblastoma, a highly malignant childhood brain tumour, impose
debilitating effects on the develo** child, and highlight the need for molecularly targeted …

While molecular subgrou** has revolutionized medulloblastoma classification, the extent
of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to …

Medulloblastoma is a malignant childhood cerebellar tumour type that comprises distinct
molecular subgroups. Whereas genomic characteristics of these subgroups are well …

Summary The Molecular Signatures Database (MSigDB) is one of the most widely used and
comprehensive databases of gene sets for performing gene set enrichment analysis. Since …

Background International consensus recognises four medulloblastoma molecular
subgroups: WNT (MB WNT), SHH (MB SHH), group 3 (MB Grp3), and group 4 (MB Grp4) …

Medulloblastoma is the most common pediatric malignant brain tumor. Advances in
molecular profiling have uncovered significant heterogeneity among medulloblastomas and …

Historical risk stratification criteria for medulloblastoma rely primarily on clinicopathological
variables pertaining to age, presence of metastases, extent of resection, histological …