Polydimethylsiloxane (PDMS) is the predominant material used for organ-on-a-chip devices
and microphysiological systems (MPSs) due to its ease-of-use, elasticity, optical …

Organoids and organs-on-chips are two rapidly emerging 3D cell culture techniques that
aim to bridge the gap between in vitro 2D cultures and animal models to enable clinically …

Organoids/organs-on-a-chip open up new frontiers for basic and clinical research of
intestinal diseases. Species-specific differences hinder research on animal models, while …

While there has been considerable success in the three-dimensional bioprinting of relatively
large standalone filamentous tissues, the fabrication of solid fibers with ultrafine diameters or …

Artificial cells are synthetic constructs that emulate natural cells, with potential applications in
areas of energy science, environmental treatment, and the study of life's origins …

The use of biomimetic models of the glomerulus has the potential to improve our
understanding of the pathogenesis of kidney diseases and to enable progress in …

The number of patients with end-stage renal disease is continuously increasing worldwide.
The only therapies for these patients are dialysis and organ transplantation, but the latter is …

We explore the utility of bioengineered human tissues—individually or connected into
physiological units—for biological research. While much smaller and simpler than their …

Engineered hydrogel patches have shown promising therapeutic effects in the treatment of
myocardial infarction (MI), especially anisotropic patches that mimic the characteristics of …

Peripheral nerve injury can lead to paralysis, chronic pain, muscle atrophy and disability due
to interrupted bioelectric signal communications between spinal cord and the innervated …