Classically, superoxide anion O2•− and reactive oxygen species ROS play a dual role. At
the physiological balance level, they are a by-product of O2 reduction, necessary for cell …

Superoxide dismutases (SODs) are a group of metalloenzymes that catalyze the dismutation
of superoxide radicals (O2˙−) into hydrogen peroxide (H2O2) and oxygen (O2). As the first …

Superoxide dismutases are enzymes that function to catalytically convert superoxide radical
to oxygen and hydrogen peroxide. These enzymes carry out catalysis at near diffusion …

The discovery of superoxide dismutases (SODs), which convert superoxide radicals to
molecular oxygen and hydrogen peroxide, has been termed the most important discovery of …

Nature uses dioxygen as a key oxidant in the transformation of biomolecules. Among the
enzymes that are utilized for these reactions are copper-containing metalloenzymes, which …

▪ Abstract Copper-zinc superoxide dismutase (CuZnSOD, SOD1 protein) is an abundant
copper-and zinc-containing protein that is present in the cytosol, nucleus, peroxisomes, and …

Crohn's disease and ulcerative colitis, known together as inflammatory bowel diseases
(IBDs), and celiac disease are the most common disorders affecting not only adults but also …

Human Cu–Zn superoxide dismutase (SOD1) protects cells from the effects of oxidative
stress. Mutations in SOD1 are linked to the familial form of amyotrophic lateral sclerosis …

Copper-containing nitrite reductases catalyze the reduction of nitrite to nitric oxide (NO), a
key step in denitrification that results in the loss of terrestrial nitrogen to the atmosphere …

Few proteins have come under such intense scrutiny as superoxide dismutase-1 (SOD1).
For almost a century, scientists have dissected its form, function and then later its …